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使用脱细胞生物工程角膜(BioCorneaVet)进行板层角膜移植治疗猫角膜腐骨:62只眼的回顾性研究(2018 - 2021年)

Lamellar Keratoplasty Using Acellular Bioengineering Cornea (BioCorneaVet) for the Treatment of Feline Corneal Sequestrum: A Retrospective Study of 62 Eyes (2018-2021).

作者信息

Xu Huihao, Sapienza John S, Jin Yipeng, Lin Jiahao, Zheng Xiaobo, Dong Haodi, Diao Hongxiu, Zhao Ying, Gao Jiafeng, Tang Jing, Feng Xueqian, Micceri Danielle, Zeng Haoran, Lin Degui

机构信息

College of Veterinary Medicine, China Agricultural University, No. 2, Yuanmingyuan West Road, Haidian District, Beijing 100193, China.

College of Veterinary Medicine, Southwest University, No. 160, Xueyuan Road, Rongchang District, Chongqing 402460, China.

出版信息

Animals (Basel). 2022 Apr 13;12(8):1016. doi: 10.3390/ani12081016.

Abstract

To retrospectively evaluate the effectiveness and outcome of lamellar keratoplasty using acellular bioengineering cornea (BioCorneaVet) for the treatment of feline corneal sequestrum (FCS). The medical records of cats diagnosed with FCS that underwent lamellar keratoplasty with BioCorneaVet between 2018 and 2021 with a minimum of 3 months of follow-up were reviewed. Follow-up examinations were performed weekly for 3 months, and then optical coherence tomography (OCT) examination was performed on select patients at 0, 3, 6, and 12 months post-operatively. A total of 61 cats (30 left eyes and 32 right eyes) were included. The Persian breed was overrepresented, 48/61 (78.69%). Four different thicknesses of acellular bioengineering cornea were used (200, 300, 400, or 450 microns), and the mean graft size was 8.23 mm (range, 5.00-12.00 mm). Minor complications were composed of partial dehiscence, and protrusion of the graft occurred in 7/62 eyes (11.29%). The median postoperative follow-up was 12.00 months (range, 3-41 months). A good visual outcome was achieved in 60/62 eyes (96.77%), and a mild to moderate corneal opacification occurred in 2/62 (3.23%). No recurrence of corneal sequestrum was observed. From the results, lamellar keratoplasty using acellular bioengineering cornea (BioCorneaVet) is an effective treatment for FCS, providing a good tectonic support and natural collagen framework, and resulting in satisfactory visual and cosmetic effects.

摘要

回顾性评估使用脱细胞生物工程角膜(BioCorneaVet)进行板层角膜移植术治疗猫角膜腐骨(FCS)的有效性和结果。回顾了2018年至2021年间诊断为FCS并接受BioCorneaVet板层角膜移植术且随访至少3个月的猫的病历。术后3个月每周进行随访检查,然后在术后0、3、6和12个月对部分患者进行光学相干断层扫描(OCT)检查。共纳入61只猫(30只左眼和32只右眼)。波斯猫品种占比过高,为48/61(78.69%)。使用了四种不同厚度的脱细胞生物工程角膜(200、300、400或450微米),平均移植片大小为8.23毫米(范围为5.00 - 12.00毫米)。轻微并发症包括部分裂开,7/62只眼(11.29%)出现移植片突出。术后中位随访时间为12.00个月(范围为3 - 41个月)。60/62只眼(96.77%)获得了良好的视觉效果,2/62只眼(3.23%)出现轻度至中度角膜混浊。未观察到角膜腐骨复发。从结果来看,使用脱细胞生物工程角膜(BioCorneaVet)进行板层角膜移植术是治疗FCS的有效方法,可提供良好的结构支撑和天然胶原框架,并产生令人满意的视觉和美容效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/9026742/a26200bcb4f7/animals-12-01016-g001.jpg

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