Khurshid Zohaib, Asiri Faris Yahya I, Najeeb Shariq, Ratnayake Jithendra
Department of Prosthodontics and Dental Materials, School of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Department of Preventive Dentistry, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Materials (Basel). 2022 Apr 10;15(8):2776. doi: 10.3390/ma15082776.
In many cases, the replanted teeth may undergo resorption or ankyloses. Recent studies show that autologous platelet concentrates (APCs) may improve the outcomes of tooth replantation. The aim of this systematic review was to summarize and critically appraise the currently available literature on the use of APCs before tooth replantation.
An electronic search was conducted on the following research databases: PubMed/MEDLINE, ISI Web of Science, EMBASE and Scopus. The following medical subject heading (MeSH) keywords used were: ((tooth replantation) OR (replanted tooth) OR (teeth replantation) OR (replanted teeth)) AND ((autologous platelet concentrate) OR (platelet-rich plasma) OR (platelet-rich fibrin) OR (autologous platelet)). The studies' data was extracted, and the research' quality was rated using the CARE and ARRIVE protocols.
Ten case reports and three animal studies, one cell study and one study, which included both animal and in vitro experiments, were included in this review. In majority of the studies, APCs improved the outcomes of tooth replantation. However, there were various sources of bias in the most of the research, which may have influenced the results.
Although majority of the studies indicate that APCs may improve outcomes of tooth replantation, majority of the studies contained numerous sources of bias. Additionally, the sample size of the included subjects is inadequate to predict the clinical efficacy of APCs in management of replanted teeth. Large-scale, multi-center and long-term studies are required to ascertain the efficacy of APCs in improve the outcomes of tooth replantation.
在许多情况下，再植牙可能会发生吸收或粘连。最近的研究表明，自体血小板浓缩物（APCs）可能会改善牙齿再植的效果。本系统评价的目的是总结并批判性评价目前关于在牙齿再植前使用APCs的现有文献。
在以下研究数据库中进行了电子检索：PubMed/MEDLINE、ISI科学网、EMBASE和Scopus。使用的医学主题词（MeSH）关键词如下：（（牙齿再植）或（再植牙）或（牙齿再植术）或（再植牙齿））和（（自体血小板浓缩物）或（富血小板血浆）或（富血小板纤维蛋白）或（自体血小板））。提取了研究数据，并使用CARE和ARRIVE方案对研究质量进行了评分。
本评价纳入了10篇病例报告、3项动物研究、1项细胞研究以及1项包括动物和体外实验的研究。在大多数研究中，APCs改善了牙齿再植的效果。然而，大多数研究存在各种偏倚来源，这可能影响了结果。
尽管大多数研究表明APCs可能会改善牙齿再植的效果，但大多数研究存在大量偏倚来源。此外，纳入研究对象的样本量不足以预测APCs在再植牙治疗中的临床疗效。需要进行大规模、多中心和长期研究，以确定APCs在改善牙齿再植效果方面的疗效。
