Suppr超能文献

双膦酸盐对牙齿再植后牙根吸收的影响——一项系统评价

Effect of bisphosphonates on root resorption after tooth replantation - a systematic review.

作者信息

Najeeb Shariq, Siddiqui Fahad, Khurshid Zohaib, Zohaib Sana, Zafar Muhammad Sohail, Ansari Shazia Akbar

机构信息

Department of Dentistry, Riyadh Consultative Clinics, Riyadh, Saudi Arabia.

Department of Pediatric Dentistry, Rutgers School of Dental Medicine, Newark, New Jersey, USA.

出版信息

Dent Traumatol. 2017 Apr;33(2):77-83. doi: 10.1111/edt.12316. Epub 2017 Jan 5.

Abstract

BACKGROUND/AIM: Replantation of avulsed teeth may lead to root resorption. Bisphosphonates (BPs), a class of drugs of used to treat resorptive diseases of the bone such as osteoporosis and Paget's disease, have been observed to exert an antiresorptive effect on periodontal bone as well. The antiresorptive properties of BPs could prove them useful in preventing root resorption of replanted avulsed teeth. The aim of this systematic review was to analyze and summarize the currently available literature concerning the use of BPs in preventing root resorption of avulsed teeth.

MATERIALS AND METHODS

PubMed/MEDLINE, Google Scholar, ISI Web of Knowledge, and Embase databases were searched using keywords 'bisphosphonate', 'replantation', and 'tooth'. Quality assessment of each study was carried out. In addition, general characteristics and outcomes of each study were summarized.

RESULTS

After exclusion of 116 irrelevant articles, 10 animal studies were included in this review. The majority of the studies suggest that surface application of zoledronate or alendronate reduces root resorption of replanted teeth in animal models. Surface treatment with etidronate had no significant effect on root resorption, and intracanal etidronate accelerated resorption.

CONCLUSION

Surface application of zoledronate and alendronate reduces root resorption of replanted teeth in animal models. However, the efficacy of intracanal usage of BPs is still debatable.

摘要

背景/目的:牙脱位再植可能导致牙根吸收。双膦酸盐(BPs)是一类用于治疗骨质疏松症和佩吉特病等骨吸收性疾病的药物,已观察到其对牙周骨也有抗吸收作用。BPs的抗吸收特性可能证明其在预防再植脱位牙的牙根吸收方面有用。本系统评价的目的是分析和总结目前关于使用BPs预防脱位牙牙根吸收的文献。

材料与方法

使用关键词“双膦酸盐”“再植”和“牙齿”检索PubMed/MEDLINE、谷歌学术、科学网和Embase数据库。对每项研究进行质量评估。此外,总结了每项研究的一般特征和结果。

结果

排除116篇无关文章后,本评价纳入了10项动物研究。大多数研究表明,在动物模型中,唑来膦酸盐或阿仑膦酸盐的表面应用可减少再植牙的牙根吸收。依替膦酸盐的表面处理对牙根吸收无显著影响,而根管内使用依替膦酸盐会加速吸收。

结论

在动物模型中,唑来膦酸盐和阿仑膦酸盐的表面应用可减少再植牙的牙根吸收。然而,BPs根管内使用的疗效仍有争议。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验