Blum C B, Levy R I
Cardiology. 1987;74(1):2-21. doi: 10.1159/000174169.
A large and convincing body of evidence links increased coronary risk with elevated plasma levels of low-density lipoprotein (LDL) cholesterol. Cholesterol in atherosclerotic lesions originates from that circulating in the blood bound to LDL. Even mild degrees of hypercholesterolemia (cholesterol greater than 180 mg/dl) when due to increased levels of LDL are associated with increased risk. Lowering plasma levels of LDL has been clearly shown to reduce coronary risk. We are able to modify plasma levels of LDL by restricting the dietary content of cholesterol and saturated fats. Such diets are safe and can be adhered to by large populations. Available information, reviewed here in detail, supports vigorous efforts to lower cholesterol levels by dietary means, even in the patient with so-called mild hypercholesterolemia. The evidence is overwhelming, the risk is nil, and the potential benefits are substantial.
大量且具有说服力的证据表明，血浆低密度脂蛋白（LDL）胆固醇水平升高与冠状动脉疾病风险增加有关。动脉粥样硬化病变中的胆固醇源于血液中与LDL结合的循环胆固醇。即使是由于LDL水平升高导致的轻度高胆固醇血症（胆固醇大于180mg/dl）也与风险增加有关。降低血浆LDL水平已被明确证明可降低冠状动脉疾病风险。我们能够通过限制饮食中胆固醇和饱和脂肪的含量来改变血浆LDL水平。这类饮食是安全的，并且大多数人都能坚持。这里详细回顾的现有信息支持大力通过饮食手段降低胆固醇水平，即使是对于所谓的轻度高胆固醇血症患者。证据确凿，风险为零，潜在益处巨大。
