放射疗法在治疗HIV感染患者的卡波西肉瘤中的作用。
The Role of Radiotherapy in Treating Kaposi's Sarcoma in HIV Infected Patients.
作者信息
Quéro Laurent, Palich Romain, Valantin Marc-Antoine
机构信息
INSERM U1160, Alloimmunity-Autoimmunity-Transplantation Research Unit, Université Paris Cité, 75006 Paris, France.
Radiation Oncology Department, DMU ICARE, Saint Louis Hospital, AP-HP, 75010 Paris, France.
出版信息
Cancers (Basel). 2022 Apr 10;14(8):1915. doi: 10.3390/cancers14081915.
Kaposi's sarcoma (KS) is a radiosensitive cancer regardless of its form (classical, endemic, AIDS-related, and immunosuppressant therapy-related). Radiotherapy (RT) is an integral part of the therapeutic management of KS. RT may be used as the main treatment, in the case of solitary lesions, or as palliative therapy in the disseminated forms. The dose of RT to be delivered is 20-30 Gy by low-energy photons or by electrons. The complete response rate after RT is high, around 80-90%. This treatment is well tolerated. However, patients should be informed of the possible risk of the development of late skin sequelae and the possibility of recurrence. With the advent of highly active antiretroviral therapy (HAART), the indications for RT treatment in HIV-positive patients have decreased.
卡波西肉瘤（KS）是一种对放疗敏感的癌症，无论其形式如何（经典型、地方性、艾滋病相关型和免疫抑制治疗相关型）。放射治疗（RT）是KS治疗管理的一个组成部分。RT可作为主要治疗方法用于孤立性病变，或作为播散型的姑息治疗。采用低能光子或电子进行放疗的剂量为20 - 30 Gy。放疗后的完全缓解率很高，约为80 - 90%。这种治疗耐受性良好。然而，应告知患者可能出现晚期皮肤后遗症以及复发的可能性。随着高效抗逆转录病毒治疗（HAART）的出现，HIV阳性患者接受RT治疗的适应症有所减少。
Zotero 插件