Ofuji Yoshiko, Katada Yusaku, Tomita Yohei, Nagai Norihiro, Sonobe Hideki, Watanabe Kazuhiro, Shinoda Hajime, Ozawa Yoko, Negishi Kazuno, Tsubota Kazuo, Kurihara Toshihide
Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Life (Basel). 2022 Apr 6;12(4):542. doi: 10.3390/life12040542.
Fundus fluorescent angiography is a standard examination in Japan that can directly visualize the circulatory failure in diabetic retinopathy but is not used in Western countries. In this study, we examine the relationship between the non-perfusion area in fundus fluorescent angiography and the progression of diabetic retinopathy. We evaluated 22 eyes between 22 patients who had their first fundus fluorescent angiography during a clinical episode at Keio University Hospital from January 2012 to May 2015, were diagnosed as having preproliferative diabetic retinopathy, and could be followed for at least three years. The non-perfusion area index (%) in nine segmented fundi in the initial fundus fluorescent angiography was calculated, and the progression to proliferative diabetic retinopathy over three years was evaluated. Three out of the 22 eyes (13.6%) developed proliferative diabetic retinopathy over three years. The non-perfusion area index for the initial fundus fluorescent angiography was significantly associated with progression to proliferative diabetic retinopathy. The non-perfusion area index in the posterior pole was most strongly correlated with the progression to proliferative diabetic retinopathy. Thus, the non-perfusion area index in the posterior pole among those with preproliferative diabetic retinopathy may predict the progression to proliferative diabetic retinopathy in the subsequent three years.
眼底荧光血管造影在日本是一项标准检查，可直接观察糖尿病视网膜病变中的循环衰竭情况，但在西方国家并不使用。在本研究中，我们研究了眼底荧光血管造影中的无灌注区与糖尿病视网膜病变进展之间的关系。我们评估了2012年1月至2015年5月在庆应义塾大学医院临床发作期间首次进行眼底荧光血管造影、被诊断为增殖前期糖尿病视网膜病变且至少可随访三年的22例患者的22只眼睛。计算了初次眼底荧光血管造影中九个分段眼底的无灌注区指数（%），并评估了三年中向增殖性糖尿病视网膜病变的进展情况。22只眼中有3只（13.6%）在三年中发展为增殖性糖尿病视网膜病变。初次眼底荧光血管造影的无灌注区指数与向增殖性糖尿病视网膜病变的进展显著相关。后极部的无灌注区指数与向增殖性糖尿病视网膜病变的进展相关性最强。因此，增殖前期糖尿病视网膜病变患者后极部的无灌注区指数可能预测随后三年向增殖性糖尿病视网膜病变的进展。
