Ahn Hye-Chan, Kim Do-Hoon, Cho Chul-Hyun, Byun Jun-Chul, Cho Jang-Hyuk
Department of Rehabilitation Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu 42601, Korea.
Department of Laboratory Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu 42601, Korea.
Children (Basel). 2022 Apr 7;9(4):528. doi: 10.3390/children9040528.
Hereditary neuropathy with liability to pressure palsy (HNPP) makes nerves increasingly susceptible to mechanical pressure at entrapment sites. Neuralgic amyotrophy (NA) can cause sudden regional weakness following events to which the patient is immunologically predisposed, such as vaccination. However, NA related to human papilloma virus (HPV) vaccination is seldom reported. We describe the case of a child with NA as the cause of a dropped shoulder following the administration of the HPV vaccine. Underlying asymptomatic HNPP was confirmed in this patient based on the electrodiagnostic findings and genetic analysis. We speculate that HPV vaccination elicited an immune-mediated inflammatory response, resulting in NA. Our patient with pre-existing HNPP might be vulnerable to the occurrence of an immune-mediated NA, which caused the dropped shoulder.
遗传性压力易感性周围神经病（HNPP）使神经在卡压部位越来越易受机械压力影响。痛性肌萎缩（NA）可在患者具有免疫易感性的事件（如接种疫苗）后导致突然的局部无力。然而，与人类乳头瘤病毒（HPV）疫苗接种相关的NA鲜有报道。我们描述了1例儿童在接种HPV疫苗后出现肩部下垂，病因是NA。根据电诊断结果和基因分析，该患者被确诊存在无症状的HNPP。我们推测HPV疫苗接种引发了免疫介导的炎症反应，导致了NA。我们这位患有HNPP的患者可能易发生免疫介导的NA，进而导致了肩部下垂。
