Lee Sang Mi, Lee Jeong Won, Lee Ji-Hyun, Jo In Young, Jang Su Jin
Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea.
Department of Nuclear Medicine, International St. Mary's Hospital, Catholic Kwandong University, Incheon 22711, Korea.
J Pers Med. 2022 Apr 7;12(4):592. doi: 10.3390/jpm12040592.
This study aimed to evaluate the prognostic significance of 2-Deoxy-2-[F]fluoro-D-glucose ([F]FDG) uptake in the bone marrow (BM) and primary tumors on dual-time-point (DTP) PET/CT for predicting progression-free survival (PFS) and distant metastasis-free survival (DMFS) in patients with non-small cell lung cancer (NSCLC). We retrospectively analyzed DTP [F]FDG PET/CT images from 211 patients with NSCLC. The maximum standardized uptake value (SUV) of primary lung cancer and mean [F]FDG uptake of the BM (BM SUV) were measured from early and delayed PET/CT images, and the percent changes in these parameters (∆maximum SUV and ∆BM SUV) were calculated. On multivariate survival analysis, the maximum SUV and BM SUV on both early and delayed PET/CT scans were significantly associated with PFS, while the ∆maximum SUV and ∆BM SUV failed to show statistical significance. For DMFS, the ∆maximum SUV and ∆BM SUV were independent predictors along with the TNM stage. Distant progression was observed only in 1.3% of patients with low ∆maximum SUV and ∆BM SUV, whereas 28.2% of patients with high ∆maximum SUV and ∆BM SUV experienced distant progression. The ∆maximum SUV and ∆BM SUV on DTP [F]FDG PET/CT were significant independent predictors for DMFS in patients with NSCLC.
本研究旨在评估双时相（DTP）PET/CT上骨髓（BM）和原发性肿瘤中2-脱氧-2-[F]氟-D-葡萄糖（[F]FDG）摄取对预测非小细胞肺癌（NSCLC）患者无进展生存期（PFS）和无远处转移生存期（DMFS）的预后意义。我们回顾性分析了211例NSCLC患者的DTP [F]FDG PET/CT图像。从早期和延迟PET/CT图像中测量原发性肺癌的最大标准化摄取值（SUV）和BM的平均[F]FDG摄取量（BM SUV），并计算这些参数的变化百分比（∆最大SUV和∆BM SUV）。在多因素生存分析中，早期和延迟PET/CT扫描上的最大SUV和BM SUV均与PFS显著相关，而∆最大SUV和∆BM SUV未显示出统计学意义。对于DMFS，∆最大SUV和∆BM SUV与TNM分期一起是独立的预测因素。仅1.3%的低∆最大SUV和∆BM SUV患者出现远处进展，而28.2%的高∆最大SUV和∆BM SUV患者出现远处进展。DTP [F]FDG PET/CT上的∆最大SUV和∆BM SUV是NSCLC患者DMFS的重要独立预测因素。
