Jones Laney K, Williams Marc S, Ladd Ilene G, Cawley Dylan, Ge Shuping, Hao Jing, Hassen Dina, Hu Yirui, Kirchner H Lester, Kobylinski Maria, Lesko Michael G, Nelson Matthew C, Rahm Alanna K, Rolston David D, Romagnoli Katrina M, Schubert Tyler J, Shuey Timothy C, Sturm Amy C, Gidding Samuel S
Heart and Vascular Institute, Geisinger, Danville, PA 17821, USA.
Genomic Medicine Institute, Geisinger, Danville, PA 17821, USA.
J Pers Med. 2022 Apr 9;12(4):606. doi: 10.3390/jpm12040606.
The Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia (CARE-FH) study aims to improve diagnostic evaluation rates for FH at Geisinger, an integrated health delivery system. This clinical trial relies upon implementation science to transition the initial evaluation for FH into primary care, attempting to identify individuals prior to the onset of atherosclerotic cardiovascular disease events. The protocol for the CARE-FH study of this paper is available online. The first phase of the project focuses on trial design, including the development of implementation strategies to deploy evidence-based guidelines. The second phase will study the intervention, rolled out regionally to internal medicine, community medicine, and pediatric care clinicians using a stepped-wedge design, and analyzing data on diagnostic evaluation rates, and implementation, service, and health outcomes.
家族性高胆固醇血症全民协作诊疗方法（CARE - FH）研究旨在提高杰弗逊医疗集团（一个综合医疗服务体系）对家族性高胆固醇血症（FH）的诊断评估率。这项临床试验依靠实施科学将FH的初始评估转变为初级保健，试图在动脉粥样硬化性心血管疾病事件发生之前识别个体。本文中CARE - FH研究的方案可在网上获取。该项目的第一阶段专注于试验设计，包括制定实施策略以推行循证指南。第二阶段将研究干预措施，采用阶梯式楔形设计在区域内推广至内科、社区医学和儿科护理临床医生，并分析诊断评估率以及实施、服务和健康结果的数据。
