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将基于证据的指南转化为临床决策支持工具,以改善家族性高胆固醇血症的识别与管理。

Translating Evidence-Based Guidelines Into Clinical Decision Support Tools to Improve Identification and Management of Familial Hypercholesterolemia.

作者信息

Shuey Timothy C, Schubert Tyler J, Romagnoli Katrina, Cawley Dylan, Jones Laney K, Gidding Samuel S, Williams Marc S

机构信息

Department of Internal Medicine, Geisinger Medical Center, Danville, PA.

Geisinger Commonwealth School of Medicine, Scranton, PA.

出版信息

AMIA Annu Symp Proc. 2025 May 22;2024:1030-1039. eCollection 2024.

PMID:40417495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12099389/
Abstract

Evidence-based clinical guidelines serve to support clinical decision making, but implementing such guidelines into practice remains a challenge. Familial hypercholesterolemia (FH) is a high impact clinical condition that exemplifies this disconnect. Using implementation science methods, we designed clinical decision support tools embedded into the electronic health record, including a FH-focused electronic health record Smart Set and clinic note template, to improve the care of adult and pediatric patients at high-risk of FH. End-user feedback gathered through direct observations, semi-structured interviews, and deliberative engagement sessions was used to inform the development of the tools before and after pilot-testing. Clinicians desired comprehensive, guidelines-based tools that promoted collaborative care. During pilot testing, end-users provided insights into technical issues encountered with the tool's first iteration and suggested regular check-in sessions to monitor issues moving forward. This methodology can be used to surmount challenges that prevent the uptake of evidence-based guidelines into practice.

摘要

循证临床指南有助于支持临床决策,但将此类指南应用于实践仍然是一项挑战。家族性高胆固醇血症(FH)是一种具有重大影响的临床病症,体现了这种脱节。我们运用实施科学方法,设计了嵌入电子健康记录的临床决策支持工具,包括以FH为重点的电子健康记录智能集和临床记录模板,以改善FH高危成年和儿科患者的护理。通过直接观察、半结构化访谈和审议参与会议收集的最终用户反馈,用于在试点测试前后为工具的开发提供信息。临床医生需要基于指南的全面工具来促进协作护理。在试点测试期间,最终用户深入了解了该工具首次迭代中遇到的技术问题,并建议定期召开检查会议以监测后续问题。这种方法可用于克服阻碍循证指南应用于实践的挑战。

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本文引用的文献

1
Using implementation science to develop a familial hypercholesterolemia screening program in primary care: The CARE-FH study.利用实施科学在初级保健中开发家族性高胆固醇血症筛查项目:CARE-FH 研究。
J Clin Lipidol. 2024 Mar-Apr;18(2):e176-e188. doi: 10.1016/j.jacl.2024.01.001. Epub 2024 Jan 4.
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Clinician Perspectives on Clinical Decision Support for Familial Hypercholesterolemia.临床医生对家族性高胆固醇血症临床决策支持的观点。
J Pers Med. 2023 May 31;13(6):929. doi: 10.3390/jpm13060929.
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Deploying Clinical Decision Support for Familial Hypercholesterolemia.为家族性高胆固醇血症部署临床决策支持
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Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia: CARE-FH Protocol.针对家族性高胆固醇血症患者实现全员覆盖的协作方法:CARE-FH方案。
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Improving clinical practice guidelines with implementation science.运用实施科学改进临床实践指南。
Nat Rev Cardiol. 2022 Jan;19(1):3-4. doi: 10.1038/s41569-021-00645-x.
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Translating an evidence-based clinical pathway into shareable CDS: developing a systematic process using publicly available tools.将循证临床路径转化为可共享的 CDS:使用公共可用工具开发系统流程。
J Am Med Inform Assoc. 2021 Jan 15;28(1):52-61. doi: 10.1093/jamia/ocaa257.
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2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.2018年美国心脏协会/美国心脏病学会/美国心血管和肺康复协会/美国医师助理学会/美国心脏协会临床心脏病学分会/美国预防医学学会/美国糖尿病协会/美国老年医学会/美国药剂师协会/美国医学主任协会/美国国家脂质协会/美国初级保健医师学会血液胆固醇管理指南:美国心脏病学会/美国心脏协会临床实践指南工作组报告
J Am Coll Cardiol. 2019 Jun 25;73(24):e285-e350. doi: 10.1016/j.jacc.2018.11.003. Epub 2018 Nov 10.
8
A Clinical Decision Support Tool for Familial Hypercholesterolemia Based on Physician Input.一种基于医生输入的家族性高胆固醇血症临床决策支持工具。
Mayo Clin Proc Innov Qual Outcomes. 2018 May 24;2(2):103-112. doi: 10.1016/j.mayocpiqo.2018.03.006. eCollection 2018 Jun.
9
Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel.家族性高胆固醇血症的临床基因检测:美国心脏病学会科学专家组。
J Am Coll Cardiol. 2018 Aug 7;72(6):662-680. doi: 10.1016/j.jacc.2018.05.044.
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Psychometric assessment of three newly developed implementation outcome measures.三种新开发的实施结果测量工具的心理计量学评估。
Implement Sci. 2017 Aug 29;12(1):108. doi: 10.1186/s13012-017-0635-3.