Nguyen Kien Trung, Le Vy Tran Thanh, Nguyen Thao Huong, Pham Suol Thanh, Nguyen Phuong Minh, Taxis Katja, Vi Mai Tuyet, Nguyen Thang, Tran Hung Do
Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City 900000, Vietnam.
Department of Pharmacy, Can Tho Children's Hospital, Can Tho City 900000, Vietnam.
Healthcare (Basel). 2022 Apr 18;10(4):751. doi: 10.3390/healthcare10040751.
Background: Children are at high risk of drug-related problems, increased risk of treatment failures, and high treatment costs. We aimed to evaluate the effect of pharmacist-led interventions on physicians’ prescribing for pediatric outpatients. Methods: A prospective study with pre- and post-intervention measurement assessment was conducted to collect pediatric outpatients’ prescriptions during the pre-intervention period (January 2020) and post-intervention (August 2020) at a children’s hospital in Vietnam. Drug-related problems were identified and categorized according to Pharmaceutical Care Network Europe (PCNE), version 9.1. The intervention program was developed based on the results of pre-intervention observations. After the intervention, prescriptions were evaluated. Statistical tests were used to compare the proportions of drug-related problems before and after the intervention and to identify factors related to drug-related problems. Results: There were 2788 out of 4218 (66.1%) prescriptions with at least one drug-related problem before the intervention. Of these drug-related problems, the most common was inappropriate timing of administration and incorrect dosage (36.1% and 35.6%, respectively). After the intervention, the percentage of prescriptions with at least one drug-related problem was 45.5% (p < 0.001). Most of the drug-related problem types decreased significantly (p < 0.05). The binary logistic regression analysis results showed that in addition to pharmacists’ intervention, patients’ gender, primary disease, comorbidity status, and the total number of drugs prescribed were also factors related to drug-related problems. Conclusions: Drug-related problems in pediatric outpatients were quite common. Pharmacists’ intervention helped to improve the prevalence and types of drug-related problems.
儿童面临药物相关问题的高风险、治疗失败风险增加以及高昂的治疗成本。我们旨在评估药剂师主导的干预措施对儿科门诊患者医生处方的影响。方法：进行一项前瞻性研究，采用干预前和干预后测量评估，以收集越南一家儿童医院在干预前期（2020年1月）和干预后期（2020年8月）儿科门诊患者的处方。根据欧洲药学保健网络（PCNE）第9.1版对药物相关问题进行识别和分类。干预方案基于干预前观察结果制定。干预后，对处方进行评估。使用统计检验比较干预前后药物相关问题的比例，并确定与药物相关问题相关的因素。结果：干预前，4218张处方中有2788张（66.1%）至少存在一个药物相关问题。在这些药物相关问题中，最常见的是给药时间不当和剂量错误（分别为36.1%和35.6%）。干预后，至少存在一个药物相关问题的处方百分比为45.5%（p<0.001）。大多数药物相关问题类型显著减少（p<0.05）。二元逻辑回归分析结果表明，除了药剂师的干预外，患者的性别、原发性疾病、合并症状态以及所开药物的总数也是与药物相关问题相关的因素。结论：儿科门诊患者的药物相关问题相当普遍。药剂师的干预有助于改善药物相关问题的发生率和类型。
