Frost H M
Clin Orthop Relat Res. 1987 Mar(216):280-97.
The minimum effective strain (MES) constitutes a threshold that separates biomechanically acceptable from unacceptable strains on growing bone and fibrous tissues. Strains above that threshold affect modeling and remodeling activities in ways that change the size and configuration of growing bones, tendons, ligaments, and fascia to fit their new mechanical usage and return their strains to the threshold level. Were that threshold set too high from birth, the effects of normal function on remodeling and modeling should lead to thin fibrous tissue structures, to slender, osteopenic diaphyses and spongiosa, and to increased fragility. Those and other predictable set point effects fit so precisely many of the known hard and soft tissue abnormalities of osteogenesis imperfecta patients, that an elevated MES set point may be a heretofore unrecognized basic pathogenetic factor in that disease.
最小有效应变（MES）构成了一个阈值，该阈值将生长中的骨骼和纤维组织上生物力学可接受的应变与不可接受的应变区分开来。高于该阈值的应变会以改变生长中骨骼、肌腱、韧带和筋膜的大小和形态的方式影响塑形和重塑活动，使其适应新的机械使用情况，并将其应变恢复到阈值水平。如果从出生起该阈值设定得过高，正常功能对重塑和塑形的影响将导致纤维组织结构变薄、骨干和松质骨细长且骨质减少，以及脆性增加。这些以及其他可预测的设定点效应与成骨不全患者许多已知的硬组织和软组织异常情况精确吻合，以至于升高的MES设定点可能是该疾病迄今为止未被认识到的基本致病因素。
