Deibel Ansgar, Meyer Zu Schwabedissen Cordula, Husmann Lars, Grimm Felix, Deplazes Peter, Reiner Cäcilia S, Müllhaupt Beat
Department of Gastroenterology and Hepatology, University Hospital Zurich, 8091 Zurich, Switzerland.
Department of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.
Pathogens. 2022 Apr 6;11(4):441. doi: 10.3390/pathogens11040441.
Since the change in the millennium, an increase in cases of alveolar echinococcosis (AE) has been observed in endemic European countries. Previous studies indicate that a significant proportion of the new AE cases have an immunosuppression-associated condition (IAC). The aim of the current study was to determine how IACs impact the number of new AE diagnoses per year and the characteristics of AE at diagnosis and its clinical course at our center.
Retrospective analysis of 189 patients with AE diagnosed between 2000 and 2021 and participating in the Zurich Echinococcosis Cohort Study (ZECS) included clinical characteristics of AE at diagnosis and report of an IAC, as well as the clinical course during follow-up.
Of 189 patients participating in this study, 38 had an IAC reported at, or shortly after, AE diagnosis. Over time, there was a steeper increase in the number of newly diagnosed AE patients without an IAC than the number of patients with IAC. Patients with an IAC were older at diagnosis, more frequently had an incidental finding of AE, smaller mean lesion size, and negative Em18 serology. All but two showed favorable outcomes on the last follow-up.
IACs have little impact on the increase in new AE cases, as well as on the extent of the disease at diagnosis and clinical course.
自千禧年以来，欧洲流行国家的肺泡型棘球蚴病（AE）病例有所增加。先前的研究表明，相当一部分新的AE病例患有免疫抑制相关疾病（IAC）。本研究的目的是确定IAC如何影响我们中心每年新诊断的AE病例数、诊断时AE的特征及其临床病程。
对2000年至2021年间诊断为AE并参与苏黎世棘球蚴病队列研究（ZECS）的189例患者进行回顾性分析，包括诊断时AE的临床特征、IAC报告以及随访期间的临床病程。
在参与本研究的189例患者中，38例在AE诊断时或诊断后不久报告有IAC。随着时间的推移，新诊断的无IAC的AE患者数量比有IAC的患者数量增长得更快。有IAC的患者诊断时年龄较大，更常因偶然发现而诊断为AE，平均病变大小较小，Em18血清学检测为阴性。除两名患者外，所有患者在最后一次随访时均显示良好预后。
IAC对新AE病例的增加以及诊断时疾病的程度和临床病程影响不大。
