Lazic Igor, Hinterwimmer Florian, Langer Severin, Pohlig Florian, Suren Christian, Seidl Fritz, Rückert Daniel, Burgkart Rainer, von Eisenhart-Rothe Rüdiger
Department of Orthopaedics and Sports Orthopaedics, Klinikum Rechts der Isar, Technical University of Munich, 80333 Munich, Germany.
Institute for AI and Informatics in Medicine, Technical University of Munich, 80333 Munich, Germany.
J Clin Med. 2022 Apr 12;11(8):2147. doi: 10.3390/jcm11082147.
Machine Learning (ML) in arthroplasty is becoming more popular, as it is perfectly suited for prediction models. However, results have been heterogeneous so far. We hypothesize that an accurate ML model for outcome prediction in THA must be able to compute arthroplasty-specific data. In this study, we evaluate a ML approach applying data from two German arthroplasty-specific registries to predict adverse outcomes after THA, after careful evaluations of ML algorithms, outcome and input variables by an interdisciplinary team of data scientists and surgeons.
Data of 1217 cases of primary THA from a single center were derived from two German arthroplasty-specific registries between 2016 to 2019. The XGBoost algorithm was adjusted and applied. Accuracy, sensitivity, specificity and AUC were calculated.
For the prediction of complications, the ML algorithm achieved an accuracy of 80.3%, a sensitivity of 31.0%, a specificity of 89.4% and an AUC of 64.1%. For the prediction of surgery duration, the ML algorithm yielded an accuracy of 81.7%, a sensitivity of 58.2%, a specificity of 91.6% and an AUC of 89.1%. The feature importance indicated non-linear outcomes for age, height, weight and surgeon. No relevant linear correlations were found.
The attunement of input and output data as well as the modifications of the ML algorithm permitted the development of a feasible ML model for the prediction of complications and surgery duration.
机器学习(ML)在关节置换术中越来越受欢迎,因为它非常适合预测模型。然而,到目前为止,结果参差不齐。我们假设,用于全髋关节置换术(THA)结果预测的准确ML模型必须能够计算关节置换术特定的数据。在本研究中,我们评估了一种ML方法,该方法应用来自两个德国关节置换术特定登记处的数据来预测THA后的不良结果,此前数据科学家和外科医生的跨学科团队对ML算法、结果和输入变量进行了仔细评估。
2016年至2019年期间,从两个德国关节置换术特定登记处获取了来自单一中心的1217例初次THA病例的数据。对XGBoost算法进行了调整并应用。计算了准确率、灵敏度、特异性和AUC。
对于并发症的预测,ML算法的准确率为80.3%,灵敏度为31.0%,特异性为89.4%,AUC为64.1%。对于手术持续时间的预测,ML算法的准确率为81.7%,灵敏度为58.2%,特异性为91.6%,AUC为89.1%。特征重要性表明年龄、身高、体重和外科医生与结果呈非线性关系。未发现相关的线性相关性。
输入和输出数据的调整以及ML算法的修改使得开发出一种可行的ML模型用于预测并发症和手术持续时间成为可能。