Department of Chemotherapy, Medical University of Lodz, Copernicus Memorial Hospital, 93-513 Lodz, Poland.
Laboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland.
Genes (Basel). 2022 Mar 28;13(4):608. doi: 10.3390/genes13040608.
Background. The role of the transcribed ultra-conserved regions (T-UCRs) has not yet been fully discovered, but the studies showed some indications that impaired expression of T-UCRS were present in malignant tumors, including breast cancer. Aim. The presented work assessed the expression of two transcribed-ultra conserved regions−uc.63 and uc.38−in breast cancer tissue samples. Material and methods. The research was carried out on a group of 100 patients with invasive ductal carcinoma and 100 patients (test group) with benign tumors in breast tissue (control group). Results. As a result of the statistical analysis, it was shown that the expression of uc.63 and uc.38 is statistically significant, and, accordingly, higher (p < 0.0001) and lower (p < 0.0001) in the test group than in the control group. Statistical dependency analysis of the expression of uc.63 and uc.38 and the selected clinical and pathological factors showed that the expression of uc.63 statistically drops with the patient’s age (p = 0.04), and is higher in the breast cancer tissue type M1 according to the TNM classification (p = 0.036) and in tissues with overexpressed HER2 (p = 0.035). Conclusion. The obtained results of the statistical analysis indicate a relationship between the expression of uc.63 and uc.38 and the occurrence of breast cancer.
转录超保守区（T-UCRs）的作用尚未完全发现，但研究表明，T-UCRS 的表达受损存在于恶性肿瘤中，包括乳腺癌。目的：本研究评估了两种转录超保守区 uc.63 和 uc.38 在乳腺癌组织样本中的表达。材料与方法：研究对象为 100 例浸润性导管癌患者和 100 例乳腺组织良性肿瘤患者（对照组）。结果：经统计学分析表明，uc.63 和 uc.38 的表达具有统计学意义，且在试验组中高于（p < 0.0001）和低于（p < 0.0001）对照组。uc.63 和 uc.38 的表达与所选临床和病理因素的统计相关性分析表明，uc.63 的表达随患者年龄呈统计学下降（p = 0.04），且根据 TNM 分类，M1 型乳腺癌组织中（p = 0.036）和过表达 HER2 的组织中（p = 0.035）表达更高。结论：统计分析的结果表明，uc.63 和 uc.38 的表达与乳腺癌的发生之间存在关联。
