Laboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland.
Department of Chemotherapy, Copernicus Memorial Hospital, Medical University of Lodz, 93-513 Lodz, Poland.
Int J Mol Sci. 2021 Aug 5;22(16):8427. doi: 10.3390/ijms22168427.
Long noncoding RNAs (lncRNAs) are the largest groups of ribonucleic acids, but, despite the increasing amount of literature data, the least understood. Given the involvement of lncRNA in basic cellular processes, especially in the regulation of transcription, the role of these noncoding molecules seems to be of great importance for the proper functioning of the organism. Studies have shown a relationship between disturbed lncRNA expression and the pathogenesis of many diseases, including cancer. The present article presents a detailed review of the latest reports and data regarding the importance of lncRNA in the development of cancers, including breast carcinoma.
长链非编码 RNA（lncRNA）是最大的核糖核酸群体，但尽管文献数据不断增加，其仍了解甚少。鉴于 lncRNA 参与基本细胞过程，尤其是转录调控，这些非编码分子的作用对于生物体的正常功能似乎非常重要。研究表明，lncRNA 表达失调与许多疾病（包括癌症）的发病机制之间存在关联。本文详细回顾了关于 lncRNA 在癌症（包括乳腺癌）发展中的重要性的最新报告和数据。
