Institute for Systems Biology, Seattle, WA 98109, USA.
Genes (Basel). 2022 Apr 17;13(4):709. doi: 10.3390/genes13040709.
The discovery and characterization of transposable element (TE) families are crucial tasks in the process of genome annotation. Careful curation of TE libraries for each organism is necessary as each has been exposed to a unique and often complex set of TE families. methods have been developed; however, a fully automated and accurate approach to the development of complete libraries remains elusive. In this review, we cover established methods and recent developments in TE analysis. We also present various methodologies used to assess these tools and discuss opportunities for further advancement of the field.
转座元件 (TE) 家族的发现和特征描述是基因组注释过程中的关键任务。由于每个生物体都暴露于独特且通常复杂的 TE 家族中,因此需要仔细整理每个生物体的 TE 文库。已经开发了多种方法;然而,完全自动化和准确的方法来开发完整的文库仍然难以实现。在这篇综述中,我们涵盖了 TE 分析的既定方法和最新进展。我们还介绍了用于评估这些工具的各种方法,并讨论了该领域进一步发展的机会。