Guarino Matteo, Perna Benedetta, Remelli Francesca, Cuoghi Francesca, Cesaro Alice Eleonora, Spampinato Michele Domenico, Maritati Martina, Contini Carlo, De Giorgio Roberto
Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, Italy.
Department of Medical Sciences, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, Italy.
Microorganisms. 2022 Apr 12;10(4):806. doi: 10.3390/microorganisms10040806.
Background: Since 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing a rapidly spreading pandemic. The present study aims to compare a modified quick SOFA (MqSOFA) score with the NEWS-2 score to predict in-hospital mortality (IHM), 30-days mortality and recovery setting. Methods: All patients admitted from March to October 2020 to the Emergency Department of St. Anna Hospital, Ferrara, Italy with clinically suspected SARS-CoV-2 infection were retrospectively included in this single-centre study and evaluated with the MqSOFA and NEWS-2 scores. Statistical and logistic regression analyses were applied to our database. Results: A total of 3359 individual records were retrieved. Among them, 2716 patients were excluded because of a negative nasopharyngeal swab and 206 for lacking data; thus, 437 patients were eligible. The data showed that the MqSOFA and NEWS-2 scores equally predicted IHM (p < 0.001) and 30-days mortality (p < 0.001). Higher incidences of coronary artery disease, congestive heart failure, cerebrovascular accidents, dementia, chronic kidney disease and cancer were found in the deceased vs. survived group. Conclusions: In this study we confirmed that the MqSOFA score was non-inferior to the NEWS-2 score in predicting IHM and 30-days mortality. Furthermore, the MqSOFA score was easier to use than NEWS-2 and is more suitable for emergency settings. Neither the NEWS-2 nor the MqSOFA scores were able to predict the recovery setting.
自2019年以来，新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发了一场迅速蔓延的大流行。本研究旨在比较改良快速序贯器官衰竭评估（MqSOFA）评分与国家早期预警评分2（NEWS-2）评分，以预测住院死亡率（IHM）、30天死亡率和康复情况。方法：回顾性纳入2020年3月至10月入住意大利费拉拉圣安娜医院急诊科、临床疑似SARS-CoV-2感染的所有患者，并用MqSOFA和NEWS-2评分进行评估。对我们的数据库进行统计和逻辑回归分析。结果：共检索到3359份个体记录。其中，2716例患者因鼻咽拭子阴性被排除，206例因数据缺失被排除；因此，437例患者符合条件。数据显示，MqSOFA和NEWS-2评分在预测IHM（p<0.001）和30天死亡率（p<0.001）方面同样有效。在死亡组与存活组中，冠心病、充血性心力衰竭、脑血管意外、痴呆、慢性肾脏病和癌症的发病率更高。结论：在本研究中，我们证实MqSOFA评分在预测IHM和30天死亡率方面不劣于NEWS-2评分。此外，MqSOFA评分比NEWS-2评分更易于使用，更适合急诊环境。NEWS-2评分和MqSOFA评分均无法预测康复情况。
