Kocijancic M, Dimkovic S
Curr Med Res Opin. 1986;10(5):313-8. doi: 10.1185/03007998609111096.
The efficacy of captopril alone or in combination with indapamide was evaluated in 17 patients with severe hypertension (diastolic greater than 120 mmHg) previously treated with triple antihypertensive therapy, i.e. diuretic, beta-blocker and a vasodilator. After a wash-out period of 1 week, captopril was given initially as 75 mg/day for 2 weeks; at the end of this period, the dosage was doubled to 150 mg/day and continued at this level for a further 2 weeks. Indapamide (2.5 mg/day) was then added to the regimen and administered for 1 month. The results showed that captopril alone lowered, but did not normalize the blood pressure. The mean diastolic pressure was reduced to 117 and 103.8 mmHg after dosages of captopril of 75 mg and 150 mg, respectively. On the addition of indapamide, the blood pressure was normalized to 93.82 mmHg mean diastolic pressure. Systolic readings were similarly reduced. Two patients developed skin rashes while on captopril alone: no other treatment-related side-effects were reported once indapamide therapy had commenced.
对17例重度高血压（舒张压大于120mmHg）患者进行了研究，评估卡托普利单独使用或与吲达帕胺联合使用的疗效，这些患者此前接受过利尿剂、β受体阻滞剂和血管扩张剂三联抗高血压治疗。经过1周的洗脱期后，最初给予卡托普利75mg/天，持续2周；在此期末，剂量加倍至150mg/天，并在此水平再持续2周。然后将吲达帕胺（2.5mg/天）添加到治疗方案中并给药1个月。结果显示，卡托普利单独使用可降低血压，但不能使其正常化。卡托普利剂量分别为75mg和150mg时，平均舒张压分别降至117mmHg和103.8mmHg。添加吲达帕胺后，血压正常化，平均舒张压为93.82mmHg。收缩压读数也有类似降低。2例患者单独使用卡托普利时出现皮疹：开始吲达帕胺治疗后未报告其他与治疗相关的副作用。
