抗磷脂抗体与血液系统恶性肿瘤中的脂质
Antiphospholipid Antibodies and Lipids in Hematological Malignancies.
机构信息
Unidad de Investigación Epidemiológica y en Servicios de Salud, CMNO OOAD Jalisco Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.
Programa de Doctorado en Farmacología, Departamento de Fisiología, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
出版信息
Int J Mol Sci. 2022 Apr 8;23(8):4151. doi: 10.3390/ijms23084151.
One of the main groups of lipids is phospholipids, which are mainly involved in forming cell membranes. Neoplastic processes such as cell replication have increased lipid synthesis, making tumor cells dependent on this synthesis to maintain their requirements. Antiphospholipid antibodies attack phospholipids in the cell membranes. Three main types of antiphospholipid antibodies are recognized: anti-β2 glycoprotein I (anti-β2GP-I), anticardiolipin (aCL), and lupus anticoagulant (LA). These types of antibodies have been proven to be present in hematological neoplasms, particularly in LH and NHL. This review on antiphospholipid antibodies in hematological neoplasms describes their clinical relationship as future implications at the prognostic level for survival and even treatment.
脂质的主要类别之一是磷脂，其主要参与构成细胞膜。肿瘤细胞的细胞复制等癌变过程增加了脂质的合成，使得肿瘤细胞依赖这种合成来维持其需求。抗磷脂抗体攻击细胞膜中的磷脂。现已确认有三种主要类型的抗磷脂抗体：抗β2 糖蛋白 I（抗β2GP-I）、抗心磷脂（aCL）和狼疮抗凝物（LA）。这些类型的抗体已被证明存在于血液系统肿瘤中，特别是在 LH 和 NHL 中。本文综述了血液系统肿瘤中的抗磷脂抗体，描述了它们在预后水平上对生存甚至治疗的潜在临床意义。
Zotero 插件