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1
Lupus anticoagulant activity of some antiphospholipid antibodies against phospholipid bound beta 2 glycoprotein I.某些抗磷脂抗体针对磷脂结合的β2糖蛋白I的狼疮抗凝活性。
J Clin Pathol. 1993 Jul;46(7):665-7. doi: 10.1136/jcp.46.7.665.
2
IgG reactivity to phospholipid-bound beta(2)-glycoprotein I is the main determinant of the fraction of lupus anticoagulant activity quenched by addition of hexagonal (II) phase phospholipid in patients with the clinical suspicion of antiphospholipid-antibody syndrome.对于临床怀疑抗磷脂抗体综合征的患者，与磷脂结合的β2糖蛋白I的IgG反应性是通过添加六方（II）相磷脂淬灭的狼疮抗凝活性部分的主要决定因素。
Haematologica. 1999 Sep;84(9):829-38.
3
The role of beta 2-glycoprotein I-dependent lupus anticoagulants in the pathogenesis of the antiphospholipid syndrome.β2糖蛋白I依赖性狼疮抗凝物在抗磷脂综合征发病机制中的作用
Verh K Acad Geneeskd Belg. 2000;62(5):353-72.
4
Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and beta 2-glycoprotein I-dependent antiphospholipid antibodies.高岭土凝血时间和稀释蝰蛇毒时间可区分凝血酶原依赖性和β2糖蛋白I依赖性抗磷脂抗体。
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Some 'antiphospholipid antibodies' bind to beta 2-glycoprotein I in the absence of phospholipid.一些“抗磷脂抗体”在没有磷脂的情况下会与β2-糖蛋白I结合。
Br J Haematol. 1992 Nov;82(3):571-4. doi: 10.1111/j.1365-2141.1992.tb06469.x.
6
Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I.自身免疫性抗磷脂抗体的狼疮抗凝活性依赖于β2-糖蛋白I。
J Clin Invest. 1992 Sep;90(3):1100-4. doi: 10.1172/JCI115926.
7
Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when beta 2-glycoprotein I is bound to a suitable surface.自身免疫性抗磷脂抗体针对的是β2-糖蛋白I与合适表面结合时所表达的一个隐蔽表位。
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"Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding.“抗心磷脂”自身抗体在无磷脂存在的情况下识别β2-糖蛋白I。抗原密度和二价结合的重要性。
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9
Exposure of anionic phospholipids upon platelet activation permits binding of beta 2 glycoprotein I and through it that of IgG antiphospholipid antibodies. Studies in platelets from patients with antiphospholipid syndrome and normal subjects.血小板活化时阴离子磷脂的暴露允许β2糖蛋白I结合，并通过它使抗磷脂抗体IgG结合。对抗磷脂综合征患者和正常受试者的血小板进行的研究。
J Autoimmun. 1994 Jun;7(3):335-48. doi: 10.1006/jaut.1994.1024.
10
Anti beta 2glycoprotein I antibodies and lupus anticoagulant in patients with recurrent pregnancy loss: prevalence and clinical significance.复发性流产患者中的抗β2糖蛋白I抗体与狼疮抗凝物：患病率及临床意义
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Role of beta 2-glycoprotein I and anti-phospholipid antibodies in activation of protein C in vitro.β2-糖蛋白I和抗磷脂抗体在体外激活蛋白C中的作用。
J Clin Pathol. 1993 Oct;46(10):908-11. doi: 10.1136/jcp.46.10.908.
2
Histones interact with anionic phospholipids with high avidity; its relevance for the binding of histone-antihistone immune complexes.组蛋白与阴离子磷脂具有高亲和力相互作用；其与组蛋白-抗组蛋白免疫复合物结合的相关性。
Clin Exp Immunol. 1994 Aug;97(2):175-80. doi: 10.1111/j.1365-2249.1994.tb06064.x.
3
Heterogeneity of antiphospholipid antibodies and their cofactors.
Clin Rev Allergy Immunol. 1995 Spring;13(1):101-6. doi: 10.1007/BF02772253.
4
Phospholipid binding specificities and idiotype expression of hybridoma derived monoclonal autoantibodies from splenic cells of patients with systemic lupus erythematosus.系统性红斑狼疮患者脾细胞来源的杂交瘤衍生单克隆自身抗体的磷脂结合特异性及独特型表达
Ann Rheum Dis. 1995 Jun;54(6):471-6. doi: 10.1136/ard.54.6.471.
5
Antigenic specificities of "antiphospholipid" autoantibodies.“抗磷脂”自身抗体的抗原特异性
Springer Semin Immunopathol. 1994;16(2-3):211-22. doi: 10.1007/BF00197518.

本文引用的文献

1
The 1982 revised criteria for the classification of systemic lupus erythematosus.1982年系统性红斑狼疮分类的修订标准。
Arthritis Rheum. 1982 Nov;25(11):1271-7. doi: 10.1002/art.1780251101.
2
Anticardiolipin antibodies: isotype distribution and phospholipid specificity.抗心磷脂抗体：同种型分布及磷脂特异性
Ann Rheum Dis. 1987 Jan;46(1):1-6. doi: 10.1136/ard.46.1.1.
3
Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986.抗心磷脂抗体检测评估：1986年4月4日举行的一次国际研讨会报告
Clin Exp Immunol. 1987 Apr;68(1):215-22.
4
Purification of antiphospholipid antibodies using a new affinity method.
Thromb Res. 1988 Dec 15;52(6):641-8. doi: 10.1016/0049-3848(88)90136-3.
5
Separation of anticardiolipin antibodies from lupus anticoagulant on a phospholipid-coated polystyrene column.
Biochem Biophys Res Commun. 1988 Sep 15;155(2):1001-7. doi: 10.1016/s0006-291x(88)80596-5.
6
Immunological specificity and mechanism of action of IgG lupus anticoagulants.
Blood. 1987 Jul;70(1):69-76.
7
Anticardiolipin antibodies and lupus anticoagulants comprise separate antibody subgroups with different phospholipid binding characteristics.抗心磷脂抗体和狼疮抗凝物构成了具有不同磷脂结合特性的独立抗体亚组。
Br J Haematol. 1989 Dec;73(4):506-13. doi: 10.1111/j.1365-2141.1989.tb00289.x.
8
Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).抗磷脂抗体针对的是一种复合抗原，该抗原包括一种脂质结合的凝血抑制剂：β2-糖蛋白I（载脂蛋白H）。
Proc Natl Acad Sci U S A. 1990 Jun;87(11):4120-4. doi: 10.1073/pnas.87.11.4120.
9
Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease.
Lancet. 1990 Jul 21;336(8708):177-8. doi: 10.1016/0140-6736(90)91697-9.
10
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor.
Lancet. 1990 Jun 30;335(8705):1544-7. doi: 10.1016/0140-6736(90)91374-j.

某些抗磷脂抗体针对磷脂结合的β2糖蛋白I的狼疮抗凝活性。

Lupus anticoagulant activity of some antiphospholipid antibodies against phospholipid bound beta 2 glycoprotein I.

作者信息

Keeling D M, Wilson A J, Mackie I J, Isenberg D A, Machin S J

机构信息

Department of Haematology, University College and Middlesex School of Medicine, London.

出版信息

J Clin Pathol. 1993 Jul;46(7):665-7. doi: 10.1136/jcp.46.7.665.

DOI:10.1136/jcp.46.7.665
PMID:8157757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC501399/
Abstract

AIMS

To determine whether beta 2 glycoprotein I (beta 2GPI) dependent anticardiolipin (aCL) antibodies detected in solid phase enzyme linked immunosorbent assays can also have lupus anticoagulant activity.

METHODS

Six anticardiolipin antibodies were affinity purified from patients with these antibodies and lupus anticoagulant activity in their plasma.

RESULTS

The anticardiolipin antibodies bound only to anionic phospholipids in the presence of beta 2GPI and bound to beta 2GPI in the absence of phospholipids. Four out of six had lupus anticoagulant activity in the dilute Russell viper venom time test.

CONCLUSIONS

The results show that some beta 2GPI dependent aCL are lupus anticoagulants. It is unclear why only some should have lupus anticoagulant activity while others do not.

摘要

目的

确定在固相酶联免疫吸附试验中检测到的β2糖蛋白I（β2GPI）依赖性抗心磷脂（aCL）抗体是否也具有狼疮抗凝活性。

方法

从血浆中存在这些抗体且具有狼疮抗凝活性的患者中亲和纯化出六种抗心磷脂抗体。

结果

抗心磷脂抗体仅在β2GPI存在时与阴离子磷脂结合，在无磷脂时与β2GPI结合。在稀释的罗素蝰蛇毒时间试验中，六种中有四种具有狼疮抗凝活性。

结论

结果表明，一些β2GPI依赖性aCL是狼疮抗凝剂。尚不清楚为何只有一些具有狼疮抗凝活性而其他的没有。