Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, China.
Int J Mol Sci. 2022 Apr 11;23(8):4226. doi: 10.3390/ijms23084226.
The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), dry eye syndrome (DES), thyroid eye disease (TED), uveitis, retinoblastoma (RB), cataract, and others, from epidemiological, clinical and basic studies, and briefly discuss vitamin D metabolism in the eye. We searched two research databases for articles examining the association between vitamin D deficiency and different ocular diseases. One hundred and sixty-two studies were found. There is evidence on the association between vitamin D and myopia, AMD, DR, and DES. Overall, 17 out of 27 studies reported an association between vitamin D and AMD, while 48 out of 54 studies reported that vitamin D was associated with DR, and 25 out of 27 studies reported an association between vitamin D and DES. However, the available evidence for the association with other ocular diseases, such as glaucoma, TED, and RB, remains limited.
维生素 D 在眼部和视觉健康中的作用一直备受关注，大量研究指出维生素 D 缺乏的不良影响。本文系统综述了近年来关于维生素 D 与不同眼部疾病（包括近视、年龄相关性黄斑变性（AMD）、青光眼、糖尿病视网膜病变（DR）、干眼症（DES）、甲状腺眼病（TED）、葡萄膜炎、视网膜母细胞瘤（RB）、白内障等）之间关联的研究结果，包括流行病学、临床和基础研究，并简要讨论了眼部的维生素 D 代谢。我们在两个研究数据库中检索了探讨维生素 D 缺乏与不同眼部疾病之间关联的文章。共发现 162 篇研究。有证据表明维生素 D 与近视、AMD、DR 和 DES 之间存在关联。总体而言，27 项研究中有 17 项报告了维生素 D 与 AMD 之间的关联，54 项研究中有 48 项报告了维生素 D 与 DR 之间的关联，27 项研究中有 25 项报告了维生素 D 与 DES 之间的关联。然而，关于维生素 D 与其他眼部疾病（如青光眼、TED 和 RB）之间关联的证据仍然有限。
