Pérez Serena Antonio, Martínez Betancourt Daisy Paola, González Del Valle Fernando, Ruiz-Moreno José M
Department of Ophthalmology, Hospital General La Mancha Centro, Ciudad Real, Alcázar de San Juan, Spain.
Department of Ophthalmology, Hospital Universitario Juan Ramón Jiménez, Ronda Exterior Norte s/n, 21005, Huelva, Spain.
Int J Retina Vitreous. 2022 Mar 7;8(1):17. doi: 10.1186/s40942-022-00368-2.
The aim of this study was to determine the 25-hydroxy vitamin D (25(OH)D) levels in age-related macular degeneration (AMD) patients.
Age-related macular degeneration (AMD) patients were classified into four groups: early AMD (N = 10), intermediate AMD (N = 12), advanced atrophic AMD (N = 19) and advanced neovascular AMD (N = 52) after undergoing fundus photography. Serum 25(OH)D levels of all subjects were evaluated. From a random control group of 326 patients whose 25(OH)D levels had been measured, a group of 93 were selected to match the age range of the AMD group. We measured 25(OH)D levels during the same period to rule out seasonal variation.
A total of 93 AMD patients (36 males and 57 females) and 93 healthy individuals (39 males and 54 females) were enrolled in this study with the mean age of 78.96 ± 8.46 vs. 78.80 ± 8.35, respectively. The patients affected by AMD had statistically significant lower 25(OH)D levels (15 ± 10 ng/mL) than the healthy subjects control group (21 ± 14 ng/mL) (p = 0.004). However, the median 25(OH)D levels in early AMD, intermediate AMD, advanced atrophic AMD and advanced neovascular AMD (12.5 ± 7.3; 15 ± 11; 15 ± 8 and 17 ± 11.5, respectively) were not statistically significant (p = 0.442).
This study shows that patients affected by AMD had lower vitamin D levels compared to healthy subjects. Further research is necessary to investigate the possible association between 25(OH)D levels and AMD.
本研究旨在测定年龄相关性黄斑变性（AMD）患者的25-羟基维生素D（25(OH)D）水平。
年龄相关性黄斑变性（AMD）患者经眼底照相后分为四组：早期AMD（N = 10）、中期AMD（N = 12）、晚期萎缩性AMD（N = 19）和晚期新生血管性AMD（N = 52）。评估所有受试者的血清25(OH)D水平。从25(OH)D水平已被测定的326例患者的随机对照组中，选取93例以匹配AMD组的年龄范围。我们在同一时期测量25(OH)D水平以排除季节变化的影响。
本研究共纳入93例AMD患者（36例男性和57例女性）和93例健康个体（39例男性和54例女性），平均年龄分别为78.96±8.46岁和78.80±8.35岁。AMD患者的25(OH)D水平（15±10 ng/mL）显著低于健康受试者对照组（21±14 ng/mL）（p = 0.004）。然而，早期AMD、中期AMD、晚期萎缩性AMD和晚期新生血管性AMD的25(OH)D水平中位数（分别为12.5±7.3；15±11；15±8和17±11.5）无统计学差异（p = 0.442）。
本研究表明，与健康受试者相比，AMD患者的维生素D水平较低。有必要进一步研究以探讨25(OH)D水平与AMD之间可能存在的关联。
