Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute of Warsaw, 04-730 Warsaw, Poland.
Department of Pharmaceutical Biochemistry, Medical University of Bialystok, 15-089 Bialystok, Poland.
Nutrients. 2022 Apr 7;14(8):1534. doi: 10.3390/nu14081534.
The ageing of the population is resulting in neurodegenerative diseases, including Alzheimer's disease (AD), which are an increasing social, economic and medical problem. Diet and physical activity are now considered as important modifiable factors that help prevent or delay the development of AD and other dementia-related diseases. The pyramid of healthy nutrition and lifestyle is a way of presenting the principles, the implementation of which gives a chance for proper development and a long healthy life. The basis of the pyramid, in the first place, is physical activity. Our review of the literature in the PubMed database supports the hypothesis that complementary factors, such as proper diet, physical exercise and mental activity, have a positive impact on the prevention of neurodegenerative diseases. The nutritional recommendations for healthy adults primarily include the consumption of vegetables, fruits, cereals, legumes, vegetable oils and fishes. Therefore, the introduction of Mediterranean and Asian diets may reduce the risk of the neurodegenerative diseases associated with dementia, whereas dairy products and meat-the main sources of L-carnitine-should be consumed in moderate amounts. The aim of our work is to provide up-to-date knowledge about the appropriate dietary model and healthy lifestyle elements and their impact on good health and the long life of people.
人口老龄化导致神经退行性疾病,包括阿尔茨海默病(AD),这是一个日益严重的社会、经济和医疗问题。饮食和体育活动现在被认为是重要的可改变因素,可以帮助预防或延缓 AD 和其他与痴呆相关疾病的发展。健康营养和生活方式金字塔是一种呈现原则的方式,实施这些原则为适当的发展和长寿提供了机会。金字塔的基础首先是体育活动。我们对 PubMed 数据库中文献的回顾支持了这样一种假设,即补充因素,如适当的饮食、体育锻炼和脑力活动,对预防神经退行性疾病有积极影响。健康成年人的营养建议主要包括蔬菜、水果、谷物、豆类、植物油和鱼类的摄入。因此,引入地中海和亚洲饮食可能会降低与痴呆相关的神经退行性疾病的风险,而乳制品和肉类——左旋肉碱的主要来源——的摄入量应适中。我们工作的目的是提供关于适当饮食模式和健康生活方式要素及其对良好健康和长寿的影响的最新知识。