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用于药物递送系统的温度/pH响应性羧甲基纤维素/聚（N-异丙基丙烯酰胺）互穿聚合物网络气凝胶

Temperature/pH-Responsive Carboxymethyl Cellulose/Poly (-isopropyl acrylamide) Interpenetrating Polymer Network Aerogels for Drug Delivery Systems.

作者信息

Liu Zhongming, Zhang Sufeng, Gao Chao, Meng Xia, Wang Shoujuan, Kong Fangong

机构信息

State Key Laboratory of Biobased Material and Green Papermaking, Key Laboratory of Pulp and Paper Science & Technology of Ministry of Education/Shandong Province, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.

Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, National Demonstration Center for Experimental Light Chemistry Engineering Education, Key Laboratory of Paper Based Functional Materials of China National Light Industry, Shaanxi University of Science and Technology, Xi'an 710021, China.

出版信息

Polymers (Basel). 2022 Apr 13;14(8):1578. doi: 10.3390/polym14081578.

DOI:10.3390/polym14081578
PMID:35458328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9029649/
Abstract

Temperature/pH-responsive carboxymethyl cellulose/poly (-isopropyl acrylamide) interpenetrating polymer network (IPN) aerogels (CMC/Ca/PNIPAM aerogels) were developed as a novel drug delivery system. The aerogel has a highly open network structure with a porosity of more than 90%, which provides convenient conditions for drug release. The morphology and structure of the CMC/Ca/PNIPAM aerogels were characterized via scanning electron microscopy (SEM), Micro-CT, X-ray photoelectron spectroscopy (XPS), pore size analysis, and cytotoxicity analysis. The analysis results demonstrate that the aerogel is non-toxic and has more active sites, temperatures, and pH response performances. The anticancer drug 5-fluorouracil (5-FU) was successfully loaded into aerogels through physical entrapment and hydrogen bonding. The drug loading and sustained-release model of aerogels are used to fit the drug loading and sustained-release curve, revealing the drug loading and sustained-release mechanism, and providing a theoretical basis for the efficient drug loading and sustained release.

摘要

温度/pH响应性羧甲基纤维素/聚（N-异丙基丙烯酰胺）互穿聚合物网络（IPN）气凝胶（CMC/Ca/PNIPAM气凝胶）被开发为一种新型药物递送系统。该气凝胶具有高度开放的网络结构，孔隙率超过90%，为药物释放提供了便利条件。通过扫描电子显微镜（SEM）、显微CT、X射线光电子能谱（XPS）、孔径分析和细胞毒性分析对CMC/Ca/PNIPAM气凝胶的形态和结构进行了表征。分析结果表明，该气凝胶无毒且具有更多的活性位点、温度和pH响应性能。抗癌药物5-氟尿嘧啶（5-FU）通过物理包埋和氢键成功负载到气凝胶中。利用气凝胶的载药和缓释模型拟合载药和缓释曲线，揭示载药和缓释机制，为高效载药和缓释提供理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/3a518c9da305/polymers-14-01578-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/89a41dfda494/polymers-14-01578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/a3c47cf0194b/polymers-14-01578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/700ce51e1d29/polymers-14-01578-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/acd41b0fc75f/polymers-14-01578-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/6e1a1a239163/polymers-14-01578-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/3e2b74563616/polymers-14-01578-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/3a518c9da305/polymers-14-01578-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/89a41dfda494/polymers-14-01578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/a3c47cf0194b/polymers-14-01578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/700ce51e1d29/polymers-14-01578-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/acd41b0fc75f/polymers-14-01578-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/6e1a1a239163/polymers-14-01578-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/3e2b74563616/polymers-14-01578-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c9b/9029649/3a518c9da305/polymers-14-01578-g007.jpg

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本文引用的文献

1
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Carbohydr Polym. 2022 Feb 1;277:118784. doi: 10.1016/j.carbpol.2021.118784. Epub 2021 Oct 20.
2
Preparation and synergistic chemo-photothermal therapy of redox-responsive carboxymethyl cellulose/chitosan complex nanoparticles.氧化还原响应性羧甲基纤维素/壳聚糖复合纳米粒子的制备及其协同化疗-光热治疗。
Carbohydr Polym. 2022 Jan 1;275:118714. doi: 10.1016/j.carbpol.2021.118714. Epub 2021 Sep 30.
3
Thermo-responsive polymers and their application as smart biomaterials.
具有超快温度响应性、机械强度高且可延展的整体无孔水凝胶：插层有羟丙基甲基纤维素的聚（N-异丙基丙烯酰胺）
Gels. 2023 Nov 24;9(12):926. doi: 10.3390/gels9120926.
4
Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications.纳米技术的新兴趋势：用于生物医学应用的气凝胶基材料
Nanomaterials (Basel). 2023 Mar 15;13(6):1063. doi: 10.3390/nano13061063.
热响应性聚合物及其作为智能生物材料的应用。
J Mater Chem B. 2017 Jun 21;5(23):4307-4321. doi: 10.1039/c7tb00157f. Epub 2017 Feb 20.
4
The advances of polysaccharide-based aerogels: Preparation and potential application.多糖基气凝胶的进展：制备与潜在应用。
Carbohydr Polym. 2019 Dec 15;226:115242. doi: 10.1016/j.carbpol.2019.115242. Epub 2019 Aug 23.
5
Carboxymethyl cellulose-based oral delivery systems.基于羧甲基纤维素的口服递药系统。
Int J Biol Macromol. 2019 Jul 15;133:21-29. doi: 10.1016/j.ijbiomac.2019.04.079. Epub 2019 Apr 13.
6
Properties and in vitro drug release of pH- and temperature-sensitive double cross-linked interpenetrating polymer network hydrogels based on hyaluronic acid/poly (N-isopropylacrylamide) for transdermal delivery of luteolin.基于透明质酸/聚（N-异丙基丙烯酰胺）的 pH 和温度双重敏感互穿聚合物网络水凝胶的性质及其对叶黄素经皮传递的体外释放。
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7
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8
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Int J Biol Macromol. 2018 Jul 15;114:1338-1344. doi: 10.1016/j.ijbiomac.2018.03.166. Epub 2018 Mar 28.
9
Synthesis and characterization of carboxymethylcellulose grafted with thermoresponsive side chains of high LCST: The high temperature and high salinity self-assembly dependence.合成与表征具有高相转变温度侧链的羧甲基纤维素接枝物：高温高盐自组装依赖性。
Carbohydr Polym. 2018 Mar 15;184:108-117. doi: 10.1016/j.carbpol.2017.12.053. Epub 2017 Dec 24.
10
Curcumin-loaded dual pH- and thermo-responsive magnetic microcarriers based on pectin maleate for drug delivery.基于马来酸酯化果胶的载姜黄素双重 pH 和温度响应磁性载药微球的制备及其药物传递性能研究。
Carbohydr Polym. 2017 Sep 1;171:259-266. doi: 10.1016/j.carbpol.2017.05.034. Epub 2017 May 11.