用于5-氟尿嘧啶释放的氧化石墨烯/羟丙基纤维素/壳聚糖复合气凝胶的制备与评价

Fabrication and Evaluation of Graphene Oxide/Hydroxypropyl Cellulose/Chitosan Hybrid Aerogel for 5-Fluorouracil Release.

作者信息

Sang Yanan, Miao Pengpai, Chen Tao, Zhao Yuan, Chen Linfeng, Tian Yayang, Han Xiaobing, Gao Jie

机构信息

School of Pharmacy, Hubei University of Science and Technology, Xianning 437100, China.

Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, Hubei University of Science and Technology, Xianning 437100, China.

出版信息

Gels. 2022 Oct 12;8(10):649. doi: 10.3390/gels8100649.

The incorporation of graphene oxide (GO) into a polymeric drug carrier can not only enhance the loading efficiency but also reduce the initial burst and consequently improve the controllability of drug release. Firstly, 5-fluorouracil (5-Fu)-loaded hydroxypropyl cellulose/chitosan (HPC/CS@5-Fu) and GO/HPC/CS@5-Fu aerogels were successfully fabricated through chemical cross-linking with glutaraldehyde. Then, the obtained aerogels were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FITR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetry (TG), and the effect of HPC and GO content on the drug loading (DL) and encapsulation efficiency (EE) for the two aerogels were investigated, respectively. Finally, the drug release behavior of the GO/HPC/CS@5-Fu aerogels with different GO content was evaluated at two different pH values, and four kinds of kinetic models were used to evaluate the release behavior.

将氧化石墨烯（GO）掺入聚合物药物载体中，不仅可以提高负载效率，还能减少初始突释，从而改善药物释放的可控性。首先，通过与戊二醛化学交联成功制备了负载5-氟尿嘧啶（5-Fu）的羟丙基纤维素/壳聚糖（HPC/CS@5-Fu）和气凝胶GO/HPC/CS@5-Fu。然后，使用扫描电子显微镜（SEM）、傅里叶变换红外光谱（FITR）、X射线衍射（XRD）、差示扫描量热法（DSC）、热重分析法（TG）对所得气凝胶进行表征，并分别研究了HPC和GO含量对两种气凝胶药物负载量（DL）和包封率（EE）的影响。最后，在两种不同的pH值下评估了不同GO含量的GO/HPC/CS@5-Fu气凝胶的药物释放行为，并使用四种动力学模型评估释放行为。