Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.
Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.
Int J Biol Macromol. 2019 Jul 15;133:21-29. doi: 10.1016/j.ijbiomac.2019.04.079. Epub 2019 Apr 13.
For administration of therapeutic agents, the oral route is favored since it is comfortable to patients and also requires a reduced cost. Recently, a considerable amount of work has been reported on carboxymethyl cellulose as oral delivery systems. In contrast to all other polysaccharides having a profile in a pharmacopeia, carboxymethyl cellulose has a hydrophilic character because of its carboxylate groups. These carboxylate groups are responsible for properties such as in situ gellation, bioadhesion, sensitivity to environmental stimuli and controlled drug release. Most of these properties can even be further improved via chemical modifications. In this review, an overview of the carboxymethyl cellulose advantages for oral delivery systems is presented.
对于治疗剂的给药，口服途径是首选，因为它使患者舒适，并且还需要降低成本。最近，已经有相当多的关于羧甲基纤维素作为口服给药系统的工作被报道。与所有在药典中有特征的其他多糖不同，由于其羧酸盐基团，羧甲基纤维素具有亲水性。这些羧酸盐基团负责一些特性，例如原位胶凝、生物黏附、对环境刺激的敏感性和控制药物释放。通过化学修饰，这些特性中的大多数甚至可以进一步改善。在这篇综述中，介绍了羧甲基纤维素在口服给药系统中的优势。
