不同变异型埃博拉病毒和马尔堡病毒的气溶胶稳定性比较及免疫缺陷小鼠中气溶胶化埃博拉病毒的毒力。

Comparison of Aerosol Stability of Different Variants of Ebola Virus and Marburg Virus and Virulence of Aerosolised Ebola Virus in an Immune-Deficient Mouse.

机构信息

Microbiology and Aerosol Sciences Group, CBR Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Wiltshire, Salisbury SP4 0JQ, UK.

出版信息

Viruses. 2022 Apr 9;14(4):780. doi: 10.3390/v14040780.

DOI:10.3390/v14040780

PMID:35458510

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9030064/

Abstract

During outbreaks of virus diseases, many variants may appear, some of which may be of concern. Stability in an aerosol of several Ebola virus and Marburg virus variants was investigated. Studies were performed measuring aerosol survival using the Goldberg drum but no significant difference in biological decay rates between variants was observed. In addition, historic data on virulence in a murine model of different Ebola virus variants were compared to newly presented data for Ebola virus Kikwit in the A129 Interferon alpha/beta receptor-deficient mouse model. Ebola virus Kikwit was less virulent than Ebola virus Ecran in our mouse model. The mouse model may be a useful tool for studying differences in virulence associated with different variants whereas aerosol stability studies may not need to be conducted beyond the species level.

摘要

在病毒疾病爆发期间，可能会出现许多变体，其中一些可能引起关注。本研究调查了几种埃博拉病毒和马尔堡病毒变体在气溶胶中的稳定性。使用 Goldberg 滚筒测量气溶胶存活时间的研究表明，变体之间的生物衰减率没有显著差异。此外，还将不同埃博拉病毒变体在鼠模型中的毒力的历史数据与新提出的埃博拉病毒基奎特在 A129 干扰素 α/β受体缺陷型鼠模型中的数据进行了比较。在我们的鼠模型中，埃博拉病毒基奎特的毒力低于埃博拉病毒 Ecran。鼠模型可能是研究与不同变体相关的毒力差异的有用工具，而气溶胶稳定性研究可能不需要在种属水平以上进行。