Department of Molecular Medicine, Mayo Clinic, Rochester, USA.
Virulence. 2021 Dec;12(1):885-901. doi: 10.1080/21505594.2021.1898169.
Ebola virus (EBOV), belonging to the species in the genus , causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While there have been six virus species classified, which each have a single type virus in the genus , CFRs of ebolavirus infections vary among viruses belonging to each distinct species. In this review, we aim to define the ebolavirus species-specific virulence on the basis of currently available laboratory and experimental findings. In addition, this review will also cover the variant-specific virulence of EBOV by referring to the unique biological and pathogenic characteristics of EBOV variant Makona, a new EBOV variant isolated from the 2013-2016 EBOV disease outbreak in West Africa. A better definition of species-specific and variant-specific virulence of ebolaviruses will facilitate our comprehensive knowledge on genus biology, leading to the development of therapeutics against well-focused pathogenic mechanisms of each Ebola disease.
埃博拉病毒（EBOV）属于丝状病毒科中的 属，可引起人类严重的发热疾病，病死率（CFR）高达 90%。虽然已经分类了六种病毒物种，每种病毒都属于单一的属病毒，但属于每个不同物种的埃博拉病毒的 CFR 有所不同。在这篇综述中，我们旨在根据目前可用的实验室和实验结果来定义埃博拉病毒的种特异性毒力。此外，本文还将通过参考 2013-2016 年西非埃博拉病毒病暴发期间分离出的新型埃博拉病毒变异株 Makona 的独特生物学和发病机制特性，涵盖 EBOV 的变异特异性毒力。更好地定义埃博拉病毒的种特异性和变异特异性毒力将有助于我们全面了解属生物学，从而开发针对每种埃博拉病的有针对性的治疗方法。
