Boreskov Institute of Catalysis, Pr. Lavrentieva 5, 630090 Novosibirsk, Russia.
Molecules. 2022 Apr 14;27(8):2538. doi: 10.3390/molecules27082538.
Asymmetric epoxidation of a series of olefinic substrates with sodium percarbonate oxidant in the presence of homogeneous catalysts based on Mn complexes with bis-amino-bis-pyridine ligands is reported. Sodium percarbonate is a readily available and environmentally benign oxidant that is studied in these reactions for the first time. The epoxidation proceeded with good to high yields (up to 100%) and high enantioselectivities (up to 99% ) using as low as 0.2 mol. % catalyst loadings. The epoxidation protocol is suitable for various types of substrates, including unfunctionalized alkenes, ,-unsaturated ketones, esters (- and -), and amides (- and -). The reaction mechanism is discussed.
报道了在均相催化剂存在下，用过碳酸钠氧化剂对一系列烯烃底物进行不对称环氧化反应。过碳酸钠是一种易得且环境友好的氧化剂，这是该反应中首次对其进行研究。使用低至 0.2 摩尔%的催化剂负载量，即可获得良好至高产率（高达 100%）和高对映选择性（高达 99%）。该环氧化方法适用于各种类型的底物，包括未官能化的烯烃、烯酮、酯（-和-）和酰胺（-和-）。讨论了反应机理。
