Laissue J A, Altermatt H J, Bally E, Gebbers J O
Exp Hematol. 1987 Feb;15(2):177-80.
Partial deuteration of mice by ingestion of 29% heavy water for 12 days prior to irradiation lessened their susceptibility to lethal doses of whole body gamma irradiation from a 60Co source. Deuteration alone slightly reduced the number of nucleated bone marrow cells, blood leukocytes, and platelets. After exposure to 8.5 Gy, all mice drank tap water. Radiation-induced destruction of hemopoietic and lymphoid tissues was of equal degree in deuterated and control animals. Conversely, nucleated bone marrow cells, blood leukocytes and platelets, endogenous spleen colonies, and thymus of deuterated mice displayed signs of an accelerated and/or enhanced regeneration. The cytokinetic changes observed in deuterated animals were consistent with a protective effect for pluripotent stem cells at the time of irradiation.
在照射前12天通过摄入29%的重水对小鼠进行部分氘化，降低了它们对来自60Co源的致死剂量全身γ射线照射的敏感性。仅氘化略微减少了有核骨髓细胞、血液白细胞和血小板的数量。在暴露于8.5 Gy后，所有小鼠改饮自来水。氘化小鼠和对照动物中辐射诱导的造血和淋巴组织破坏程度相同。相反，氘化小鼠的有核骨髓细胞、血液白细胞和血小板、内源性脾集落和胸腺显示出加速和/或增强再生的迹象。在氘化动物中观察到的细胞动力学变化与照射时对多能干细胞的保护作用一致。
