Division of Neuro-Oncology, Department of Neuroscience "Rita Levi Montalcini", University and City of Health and Science University Hospital, 10126 Turin, Italy.
Department of Neuroscience "Rita Levi Montalcini", University of Turin and City of Health and Science University Hospital, 10126 Turin, Italy.
Int J Mol Sci. 2023 Jun 26;24(13):10669. doi: 10.3390/ijms241310669.
Research regarding the mechanisms of brain damage following radiation treatments for brain tumors has increased over the years, thus providing a deeper insight into the pathobiological mechanisms and suggesting new approaches to minimize this damage. This review has discussed the different factors that are known to influence the risk of damage to the brain (mainly cognitive disturbances) from radiation. These include patient and tumor characteristics, the use of whole-brain radiotherapy versus particle therapy (protons, carbon ions), and stereotactic radiotherapy in various modalities. Additionally, biological mechanisms behind neuroprotection have been elucidated.
近年来，针对脑肿瘤放射治疗后脑损伤机制的研究不断增加，从而深入了解了其病理生物学机制，并提出了减少这种损伤的新方法。本文综述了已知会影响放射治疗后脑损伤（主要为认知障碍）风险的不同因素。这些因素包括患者和肿瘤的特征、全脑放疗与粒子治疗（质子、碳离子）的应用，以及各种立体定向放疗方式。此外，还阐明了神经保护的生物学机制。
