Department of Pathology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, 3584 CX, the Netherlands.
Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands.
BMC Cancer. 2022 Apr 22;22(1):444. doi: 10.1186/s12885-022-09533-0.
Recurrences remain an important problem in laryngeal squamous cell carcinoma. Little has been described about histological characteristics of the primary laryngeal tumor that may be associated with recurrences. Identifying risk factors for recurrences might help in adapting treatment or follow-up. Using real-life population-based data, we aimed to identify histological features of the primary tumor associated with recurrences and overall survival.
Demographic, clinical and treatment information on all first primary invasive laryngeal tumors diagnosed in 2010-2014 (N = 3705) were extracted from the population-based nationwide Netherlands cancer registry (NCR) and linked to PALGA, the nationwide Dutch pathology registry, to obtain data on histological factors and recurrences. For a random 1502 patients histological information i.e., keratinization, perineural invasion (PNI+), vascular invasion (VI+), growth pattern, degree of differentiation, extracapsular spread (ECS+), cartilage- and bone invasion and extralaryngeal extension, was manually extracted from narrative pathology reports and analyzed for locoregional recurrence and overall survival using cox regression analysis.
In total, 299 patients developed a locoregional recurrence and 555 patients died. Keratinization (HR = 0.96 (95%CI: 0.68-1.34) p = 0.79), two or three adverse characteristics (PNI+, VI+, non-cohesive growth) (HR = 1.38 (95% CI: 0.63-3.01) p = 0.42), and ECS+ (HR = 1.38 (95% CI: 0.48-4.02) p = 0.55) were not associated to recurrence. For death, also no significant association was found.
In this population-based real-life dataset on laryngeal carcinoma in the Netherlands, histological factors were not associated with locoregional recurrences or overall survival, but future studies should investigate the role of these features in treatment decisions.
在喉鳞状细胞癌中，复发仍然是一个重要的问题。关于可能与复发相关的原发喉肿瘤的组织学特征，描述甚少。识别复发的危险因素可能有助于调整治疗或随访。本研究使用真实的基于人群的临床数据，旨在确定与复发和总生存相关的原发肿瘤的组织学特征。
从全国性荷兰癌症登记处（NCR）提取 2010-2014 年诊断的所有原发性侵袭性喉肿瘤的人口统计学、临床和治疗信息（N=3705），并与全国性荷兰病理登记处 PALGA 链接，以获取组织学因素和复发的数据。对于随机的 1502 例患者，从叙述性病理报告中手动提取组织学信息，如角化、神经周围浸润（PNI+）、血管浸润（VI+）、生长模式、分化程度、囊外扩散（ECS+）、软骨和骨浸润以及喉外延伸，并使用 COX 回归分析分析局部区域复发和总生存。
共有 299 例患者出现局部区域复发，555 例患者死亡。角化（HR=0.96（95%CI：0.68-1.34），p=0.79）、两个或三个不良特征（PNI+、VI+、非黏附性生长）（HR=1.38（95%CI：0.63-3.01），p=0.42）和 ECS+（HR=1.38（95%CI：0.48-4.02），p=0.55）与复发无关。对于死亡，也没有发现显著相关性。
在这项关于荷兰喉癌的基于人群的真实临床数据中，组织学因素与局部区域复发或总生存无关，但未来的研究应探讨这些特征在治疗决策中的作用。
