Hudec Martin, Vysočanová Petra, Brázdil Vojtěch, Poloczek Martin, Hetmer Martin, Doubková Martina, Kala Petr
Vnitr Lek. 2021 Winter;67(E-7):18-23.
Amiodarone is one of the more frequently used drugs in the treatment of supraventricular and ventricular arrhythmias. Many adverse effects, more or less serious, are associated with its administration. Amiodaron-induced pulmonary toxicity (AIPT) is quite rare but represents one of the most severe adverse effects with high mortality. We present an 80 years old patient, who used amidorane due to paroxysmal atrial fibrillation for several years. Within 3 months, he was repeatedly hospitalized for a bilateral pneumonia. Eventually, AIPT was diagnosed. Early diagnosis, proper therapy of AIPT and changed antiarrhythmic therapy has significantly improved the clinical status of our patient. In this case we demonstrate typical clinical presentations of AIPT as well as the most common diagnostic procedures and recommended treatment methods. Finally, some other commonly used therapeutical options for supraventricular arrhythmias are mentioned. Future options are outlined.
胺碘酮是治疗室上性和室性心律失常时较常用的药物之一。其使用会伴随许多或轻或重的不良反应。胺碘酮诱发的肺毒性（AIPT）相当罕见，但却是最严重的不良反应之一，死亡率很高。我们报告一名80岁患者，因阵发性心房颤动使用胺碘酮数年。3个月内，他因双侧肺炎反复住院。最终，确诊为AIPT。AIPT的早期诊断、恰当治疗以及更改抗心律失常治疗方案显著改善了我们这位患者的临床状况。在这个病例中，我们展示了AIPT的典型临床表现以及最常见的诊断程序和推荐的治疗方法。最后，提及了一些其他常用的室上性心律失常治疗选择。并概述了未来的选择。
