Mid Yorkshire Hospitals NHS Trust, Wakefield, UK.
Mid Yorkshire Hospitals NHS Trust, Aberford Road, Wakefield WF1 4DG, UK, Email:
J R Coll Physicians Edinb. 2021 Mar;51(1):61-64. doi: 10.4997/JRCPE.2021.115.
Amiodarone is a common medication used widely in clinical practice. It is a triiodinated antiarrhythmic associated with a variety of adverse effects both pulmonary and extrapulmonary, the most serious being amiodarone-induced pulmonary toxicity (AIPT) or amiodarone lung. This can present with a variety of clinical syndromes ranging from subacute symptoms to an indolent and a progressive course thus mimicking an alternative diagnosis. We report a case of amiodarone lung in a female who presented with an acute fulminant progressive pneumonitis despite being on very low dose (100 mg once daily) that proved fatal. Diagnosis was made on postmortem examination due to a diagnostic conundrum. Despite the steady decrease of AIPT with reduced dose, it is vital for the treating clinicians to monitor regularly for adverse effects and review the need for long-term use to prevent complications.
胺碘酮是一种在临床实践中广泛使用的常见药物。它是一种三碘抗心律失常药物，与各种肺外和肺外不良影响有关，最严重的是胺碘酮诱导的肺毒性（AIPT）或胺碘酮肺。它可以表现出多种临床综合征，从亚急性症状到慢性和进行性过程，因此模仿了另一种诊断。我们报告了一例女性胺碘酮肺的病例，尽管她的剂量非常低（每天 100 毫克），但她仍出现急性暴发性进行性肺炎，最终导致死亡。由于诊断难题，该诊断是在尸检时做出的。尽管随着剂量的减少，AIPT 逐渐减少，但对于治疗临床医生来说，定期监测不良反应并审查长期使用的必要性以预防并发症至关重要。
