Hu Yiwei, Qu Huiting, He Jie, Zhong Hongyao, He Shoukai, Zhao Peng, Zhang Leyao, Chen Jinghua, Deng Chao
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Affiliated Hospital of Jiangnan University, Wuxi, China.
Pharmazie. 2022 Apr 10;77(3):112-117. doi: 10.1691/ph.2022.11082.
Exosomes are a type of nanoparticles in 40-200 nm extracellular vesicles secreted from living cells, containing a plurality of biologically active substances, which can be used as carriers of intercellular delivery signals. Among them, mesenchymal stem cell (MSC)-derived exosomes have been reported to play important roles in injury repair, alleviating inflammation; thus, MSC-derived exosomes have become hot spot in noncellular therapies. The role of human placental MSC-derived exosomes (hplMSC-Exos) in inflammation and their potential mechanisms are unclear. Therefore, we investigated the anti-inflammatory effects of hplMSC-Exos in lipopolysaccharide (LPS)-induced RAW264.7 cells and their intrinsic mechanisms. Our data demonstrated that hplMSCs-Exos can adjust inflammation by regulating TLR4-mediated NF-κB/MAPK and PI3K signaling pathways, indicating that hplMSCs-Exos can act as a new strategy for inflammatory treatment.
外泌体是一种直径为40-200纳米的纳米颗粒，是活细胞分泌的细胞外囊泡，含有多种生物活性物质，可作为细胞间传递信号的载体。其中，间充质干细胞（MSC）来源的外泌体已被报道在损伤修复、减轻炎症中发挥重要作用；因此，MSC来源的外泌体已成为非细胞治疗的热点。人胎盘间充质干细胞来源的外泌体（hplMSC-Exos）在炎症中的作用及其潜在机制尚不清楚。因此，我们研究了hplMSC-Exos对脂多糖（LPS）诱导的RAW264.7细胞的抗炎作用及其内在机制。我们的数据表明，hplMSCs-Exos可通过调节TLR4介导的NF-κB/MAPK和PI3K信号通路来调节炎症，这表明hplMSCs-Exos可作为一种新的炎症治疗策略。
