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Respiratory effects of thyrotropin-releasing hormone and its analogue taltirelin on opioid-induced respiratory depression.

作者信息

Algera Marijke H, Cotten Joseph F, van Velzen Monique, Niesters Marieke, Boon Martijn, Shoham Daniel S, Dandrea Kaye E, van der Schrier Rutger, Dahan Albert

机构信息

Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.

Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

出版信息

Br J Anaesth. 2022 Jul;129(1):e4-e6. doi: 10.1016/j.bja.2022.03.022. Epub 2022 Apr 19.

DOI:10.1016/j.bja.2022.03.022
PMID:35459532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9428912/
Abstract
摘要

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1
Respiratory effects of thyrotropin-releasing hormone and its analogue taltirelin on opioid-induced respiratory depression.促甲状腺激素释放激素及其类似物他替瑞林对阿片类药物所致呼吸抑制的呼吸作用
Br J Anaesth. 2022 Jul;129(1):e4-e6. doi: 10.1016/j.bja.2022.03.022. Epub 2022 Apr 19.
2
Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression?促甲状腺素释放激素（TRH）及其类似物塔尔替林是否是阿片类药物引起的呼吸抑制的可行逆转剂？
Pharmacol Res Perspect. 2022 Jun;10(3):e00974. doi: 10.1002/prp2.974.
3
Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats.静脉内和气管内促甲状腺素释放激素及其类似物塔尔替林逆转异氟烷麻醉大鼠阿片类药物引起的呼吸抑制。
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4
Thyrotropin-releasing hormone analog as a stable upper airway-preferring respiratory stimulant with arousal properties.促甲状腺素释放激素类似物作为一种稳定的上气道偏好性呼吸兴奋剂，具有觉醒特性。
J Appl Physiol (1985). 2022 Nov 1;133(5):1067-1080. doi: 10.1152/japplphysiol.00414.2022. Epub 2022 Sep 22.
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The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems.合成促甲状腺激素释放激素类似物他替瑞林通过不同的下行单胺能系统发挥模式特异性的镇痛作用。
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Sleep. 2020 Sep 14;43(9). doi: 10.1093/sleep/zsaa053.

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Optical and pharmacological manipulation of hypoglossal motor nucleus identifies differential effects of taltirelin on sleeping tonic motor activity and responsiveness.舌下运动核的光学和药理学操作鉴定了塔替瑞林对睡眠紧张性运动活动和反应性的不同影响。
Sci Rep. 2023 Jul 29;13(1):12299. doi: 10.1038/s41598-023-39562-z.
2
Thyrotropin-releasing hormone analog as a stable upper airway-preferring respiratory stimulant with arousal properties.促甲状腺素释放激素类似物作为一种稳定的上气道偏好性呼吸兴奋剂，具有觉醒特性。
J Appl Physiol (1985). 2022 Nov 1;133(5):1067-1080. doi: 10.1152/japplphysiol.00414.2022. Epub 2022 Sep 22.
3
Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression?促甲状腺素释放激素（TRH）及其类似物塔尔替林是否是阿片类药物引起的呼吸抑制的可行逆转剂？
Pharmacol Res Perspect. 2022 Jun;10(3):e00974. doi: 10.1002/prp2.974.

本文引用的文献

1
Advances in Reversal Strategies of Opioid-induced Respiratory Toxicity.阿片类药物所致呼吸毒性的逆转策略进展
Anesthesiology. 2022 Apr 1;136(4):618-632. doi: 10.1097/ALN.0000000000004096.
2
A Comparison of Breathing Stimulants for Reversal of Synthetic Opioid-Induced Respiratory Depression in Conscious Rats.阿片类药物诱导的呼吸抑制的清醒大鼠的呼吸兴奋剂的比较。
J Pharmacol Exp Ther. 2021 Aug;378(2):146-156. doi: 10.1124/jpet.121.000675. Epub 2021 May 21.
3
Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats.静脉内和气管内促甲状腺素释放激素及其类似物塔尔替林逆转异氟烷麻醉大鼠阿片类药物引起的呼吸抑制。
J Pharmacol Exp Ther. 2018 Jul;366(1):105-112. doi: 10.1124/jpet.118.248377. Epub 2018 Apr 19.
4
Esketamine counters opioid-induced respiratory depression.依他佐辛对抗阿片类药物引起的呼吸抑制。
Br J Anaesth. 2018 May;120(5):1117-1127. doi: 10.1016/j.bja.2018.02.021. Epub 2018 Mar 26.
5
Novel thyrotropin-releasing hormone analogs: a patent review.新型促甲状腺激素释放激素类似物：专利研究综述。
Expert Opin Ther Pat. 2011 Nov;21(11):1673-91. doi: 10.1517/13543776.2011.623127.
6
Thyrotropin-releasing hormone receptors -- similarities and differences.促甲状腺激素释放激素受体——异同点
J Mol Endocrinol. 2003 Apr;30(2):87-97. doi: 10.1677/jme.0.0300087.
7
The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: implications for TRH-based therapeutics.促甲状腺激素释放激素（TRH）稳态调节假说：对基于TRH的治疗方法的启示。
J Pharmacol Exp Ther. 2003 May;305(2):410-6. doi: 10.1124/jpet.102.044040. Epub 2003 Feb 20.
8
The pre-Bötzinger complex participates in generating the respiratory effects of thyroliberin.前包钦格复合体参与产生促甲状腺素释放激素的呼吸效应。
Neurosci Behav Physiol. 1999 May-Jun;29(3):321-6. doi: 10.1007/BF02465344.
9
Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat.右美托咪定通过中枢α-2肾上腺素能受体发挥作用，可预防大鼠阿片类药物诱导的肌肉强直。
Anesthesiology. 1989 Aug;71(2):242-9. doi: 10.1097/00000542-198908000-00013.
10
Thyrotropin-releasing hormone has stimulatory effects on ventilation in humans.促甲状腺激素释放激素对人体的通气有刺激作用。
Acta Physiol Scand. 1991 Mar;141(3):309-18. doi: 10.1111/j.1748-1716.1991.tb09086.x.