Inyushkin A N, Merkulova N A, Chepurnov S A
Department of Human and Animal Physiology, The State University, Samara, Russia.
Neurosci Behav Physiol. 1999 May-Jun;29(3):321-6. doi: 10.1007/BF02465344.
Experiments on anesthetized rats were performed to study the effects of microinjection of thyroliberin (10 fM-100 microM) into the area of the pre-Bötzinger complex on respiratory and circulatory parameters. Thyroliberin dose-dependently increased respiration frequency, with shortening of inspiration and expiration. Tidal volume and the amplitude of the integrated EMG recorded from the inspiratory muscles decreased after administration of concentrated solutions. Using this dosage method, thyroliberin had weak effects on systemic hemodynamics. The data suggest that structures located in the area of the pre-Bötzinger complex take part in generating the respiratory effects of thyroliberin.
在麻醉大鼠身上进行实验，以研究向pre - Bötzinger复合体区域微量注射促甲状腺素释放激素（10 fM - 100 microM）对呼吸和循环参数的影响。促甲状腺素释放激素剂量依赖性地增加呼吸频率，吸气和呼气时间缩短。给予浓缩溶液后，潮气量和从吸气肌记录的综合肌电图幅度降低。采用这种给药方法，促甲状腺素释放激素对全身血流动力学的影响较弱。数据表明，位于pre - Bötzinger复合体区域的结构参与产生促甲状腺素释放激素的呼吸效应。
