断裂诱导复制：解析每一步骤
Break-induced replication: unraveling each step.
作者信息
Liu Liping, Malkova Anna
机构信息
Department of Biology, University of Iowa, Iowa City, IA 52242, USA.
Department of Biology, University of Iowa, Iowa City, IA 52242, USA.
出版信息
Trends Genet. 2022 Jul;38(7):752-765. doi: 10.1016/j.tig.2022.03.011. Epub 2022 Apr 19.
Abstract
Break-induced replication (BIR) repairs one-ended double-strand DNA breaks through invasion into a homologous template followed by DNA synthesis. Different from S-phase replication, BIR copies the template DNA in a migrating displacement loop (D-loop) and results in conservative inheritance of newly synthesized DNA. This unusual mode of DNA synthesis makes BIR a source of various genetic instabilities like those associated with cancer in humans. This review focuses on recent progress in delineating the mechanism of Rad51-dependent BIR in budding yeast. In addition, we discuss new data that describe changes in BIR efficiency and fidelity on encountering replication obstacles as well as the implications of these findings for BIR-dependent processes such as telomere maintenance and the repair of collapsed replication forks.
摘要
断裂诱导复制（BIR）通过侵入同源模板随后进行DNA合成来修复单端双链DNA断裂。与S期复制不同，BIR在迁移的置换环（D环）中复制模板DNA，并导致新合成DNA的保守遗传。这种不寻常的DNA合成模式使BIR成为各种遗传不稳定性的来源，就像人类癌症相关的那些不稳定性一样。本综述重点关注在阐明芽殖酵母中Rad51依赖性BIR机制方面的最新进展。此外，我们讨论了新数据，这些数据描述了遇到复制障碍时BIR效率和保真度的变化，以及这些发现对依赖BIR的过程（如端粒维持和塌陷复制叉的修复）的影响。
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本文引用的文献
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