Department of Haematology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, China.
Department of Rheumatology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
J Infect Chemother. 2022 Aug;28(8):1182-1188. doi: 10.1016/j.jiac.2022.04.014. Epub 2022 Apr 19.
Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is a relatively rare disease with low malignancy, and its aetiology is unclear. A 65-year-old man presented with abdominal pain. Hepatitis virus examination revealed a previous hepatitis B virus (HBV) infection, and a carbon-13 urea breath test result was positive for the patient. Abdominal contrast-enhanced computed tomography revealed a patch of abnormal density in the right posterior lobe of the liver. The patient underwent VI segment hepatectomy and was pathologically diagnosed with hepatic MALT lymphoma. After the operation, he received quadruple anti-Helicobacter pylori (HP) therapy and refused other treatments. He has been followed up by telephone for 20 months after discharge and is now in a stable condition. In this study, we counted 105 cases of hepatic MALT lymphomas reported in English or Chinese since 1995 and summarised the clinical characteristics and concomitant diseases in this condition. Based on the literature review, we speculated that chronic infectious diseases, especially viral infections (including hepatitis C virus (HCV) and HBV) and HP infection, are associated with the pathogenesis of primary hepatic MALT lymphoma. In addition, autoimmune diseases might also play a role in this condition.
原发性肝脏黏膜相关淋巴组织（MALT）淋巴瘤是一种相对罕见的低度恶性疾病，其病因尚不清楚。一名 65 岁男性因腹痛就诊。肝炎病毒检查显示患者曾感染乙型肝炎病毒（HBV），碳-13 尿素呼气试验结果为阳性。腹部增强 CT 显示肝脏右后叶有一片异常密度区。患者接受了 VI 段肝切除术，术后病理诊断为肝 MALT 淋巴瘤。术后，他接受了四联抗幽门螺杆菌（HP）治疗，拒绝了其他治疗。出院后通过电话随访 20 个月，目前情况稳定。本研究对 1995 年以来英文和中文文献报道的 105 例肝 MALT 淋巴瘤进行了总结，分析了该疾病的临床特征和伴发疾病。通过文献复习，我们推测慢性传染病，特别是病毒感染（包括丙型肝炎病毒（HCV）和 HBV）和 HP 感染，与原发性肝脏 MALT 淋巴瘤的发病机制有关。此外，自身免疫性疾病也可能在这种情况下发挥作用。
