Universidad Peruana Cayetano Heredia, School of Medicine, Lima, Peru.
Hospital Cayetano Heredia, Lima, Peru.
J Perinatol. 2022 Jul;42(7):965-970. doi: 10.1038/s41372-022-01388-4. Epub 2022 Apr 22.
Unnecessary early antibiotic exposure is deleterious, it may induce the selection of multi-drug-resistant organisms. The objective of this project was to decrease antibiotic exposure of newborns admitted to the neonatal intensive care unit at Hospital Cayetano Heredia, a level 3 unit in Lima, Peru.
Quality improvement project in which we implemented an antibiotic stewardship program for early onset sepsis in the neonatal intensive care unit. Primary outcome measure was antibiotic usage rate, total number of days infants were exposed to antibacterial agents divided by 1000 patient-days.
Antibiotic usage rate declined from 291/1000 patient-days to 82/1000 patient-days during the last months of 2020, representing a total decrease of 65.1%.
Antibiotic stewardship for early-onset sepsis implemented in a perinatal center like ours is effective, appears to be safe and results in a sustained and significant decrease in the use of antibiotics for early-onset sepsis.
不必要的早期抗生素暴露是有害的，它可能会导致多药耐药菌的选择。本项目的目的是减少秘鲁利马三级医院卡耶塔诺·埃雷迪亚医院新生儿重症监护病房新生儿的抗生素暴露。
我们在新生儿重症监护病房实施了早期败血症抗生素管理计划的质量改进项目。主要观察指标是抗生素使用率，即婴儿暴露于抗菌药物的总天数除以 1000 名患者-天。
2020 年最后几个月，抗生素使用率从 291/1000 患者-天降至 82/1000 患者-天，总降幅为 65.1%。
在我们这样的围产期中心实施的早期败血症抗生素管理计划是有效的，似乎是安全的，并能持续显著减少早期败血症的抗生素使用。
