Aafi Ensiye, Shams Ardakani Mohammad Reza, Ahmad Nasrollahi Saman, Mirabzadeh Ardakani Mehran, Samadi Aniseh, Hajimahmoodi Mannan, Naeimifar Atefeh, Pourjabbar Zeinab, Amiri Fateme, Firooz Alireza
Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Dermatol Ther. 2022 Jul;35(7):e15535. doi: 10.1111/dth.15535. Epub 2022 Apr 30.
Ziziphus jujuba Mill. (jujube) is an invaluable medicinal plant in traditional and modern medicine. Jujube syrup is a complex of herbal extracts including Z. jujuba, Berberis vulgaris, Rhus coriaria, Prunus domestica, and Rosa damascene. The purpose of the present study was to formulate and investigate the efficacy and safety of jujube syrup on brightening of facial skin. In this randomized, double-blind, controlled clinical study, 46 participants consumed jujube syrup or placebo (23 in each group) twice a day for 8 weeks. The number of pigments, area of pigmentation, and physician's global assessment score (PGAS) were evaluated at baseline and after 8 weeks. The results showed the amounts of total phenolics and flavonoids were 81.97 ± 0.25 and 4.98 ± 1.04 mg/ml, respectively. The amounts of organic acids (gallic acid and chlorogenic acid) were quantified at 1140 ± 17.65 and 1520 ± 25.77 μg/ml, respectively. The amounts of total phenolic and flavonoids were stable under accelerated conditions. Eight weeks after treatment, the number of pigment counts reduced to 0.545 ± 0.307 compared to the placebo group. Moreover, the pigmented area and its percentages were significantly reduced to 0.556 ± 0.285 and 0.561 ± 0.288 in jujube syrup compared with placebo, respectively. Jujube syrup is efficient and safe for treating hyperpigmentation of the face.
酸枣（酸枣）是传统医学和现代医学中一种非常珍贵的药用植物。枣糖浆是一种草药提取物的复合物，包括酸枣、小檗、盐肤木、欧洲李和大马士革蔷薇。本研究的目的是配制并研究枣糖浆对面部皮肤美白的功效和安全性。在这项随机、双盲、对照临床研究中，46名参与者每天服用两次枣糖浆或安慰剂（每组23人），持续8周。在基线和8周后评估色素数量、色素沉着面积和医生整体评估评分（PGAS）。结果显示，总酚和黄酮的含量分别为81.97±0.25和4.98±1.04毫克/毫升。有机酸（没食子酸和绿原酸）的含量分别定量为1140±17.65和1520±25.77微克/毫升。在加速条件下，总酚和黄酮的含量保持稳定。治疗8周后，与安慰剂组相比，色素计数降至0.545±0.307。此外，与安慰剂相比，枣糖浆组的色素沉着面积及其百分比分别显著降至0.556±0.285和0.561±0.288。枣糖浆治疗面部色素沉着有效且安全。
