Department of Respiratory and Critical Care Medicine, China Rehabilitation Research Center, Rehabilitation School of Capital Medical University, Beijing, 100068, China.
Department of Respiratory and Critical Care Medicine, China Rehabilitation Research Center, Rehabilitation School of Capital Medical University, Beijing, 100068, China.
Respir Med Res. 2022 May;81:100910. doi: 10.1016/j.resmer.2022.100910. Epub 2022 Apr 20.
We aimed to assess the effectiveness of exercise training in patients with bronchiectasis in terms of exercise capacity, pulmonary function, and quality of life.
PubMed, Embase, and the Cochrane Library were searched for randomized controlled trials (RCTs) examining pulmonary rehabilitation to treat bronchiectasis, and the search timeline was from inception through November 2020. Two researchers independently screened the literature, extracted data, evaluated the risk of bias in the included studies, and used Review Manager 5.3 software to perform the meta-analysis. The primary outcomes were incremental shuttle walk distance (ISWD) and 6-minute walk distance (6-MWD) at 8 weeks. The secondary outcomes were forced expiratory volume in 1 second (FEV1), St. George's Respiratory Questionnaire (SGRQ) score, and Leicester Cough Questionnaire (LCQ) score at 8 weeks.
A total of five RCTs with a total of 198 patients were included. A pooled analysis showed that improvements in ISWD (mean difference [MD] = 92.47 m, 95% confidence interval [CI] 49.87, 135.08; P < 0.0001), 6-MWD (MD = 31.01 m, 95% CI 1.60, 60.42; P = 0.04), and FEV1 (MD = 0.08 L, 95% CI 0.04, 0.12; P = 0.0002) in the pulmonary rehabilitation group were more marked than in the control group. There was no significant difference between the two groups in terms of the improvement in SGRQ and LCQ scores.
Pulmonary rehabilitation improves exercise capacity and pulmonary function (specifically FEV1) in patients with bronchiectasis. However, due to limitations in the number and quality of current studies, the above conclusions need to be verified in future research.
评估运动训练对支气管扩张症患者运动能力、肺功能和生活质量的疗效。
检索 PubMed、Embase 和 Cochrane Library 中关于肺康复治疗支气管扩张症的随机对照试验（RCT），检索时间从建库至 2020 年 11 月。由 2 位研究者独立筛选文献、提取资料、评估纳入研究的偏倚风险，并采用 Review Manager 5.3 软件进行荟萃分析。主要结局指标为 8 周时的递增式 shuttle 步行距离（ISWD）和 6 分钟步行距离（6-MWD）。次要结局指标为 8 周时的第 1 秒用力呼气容积（FEV1）、圣乔治呼吸问卷（SGRQ）评分和莱斯特咳嗽问卷（LCQ）评分。
共纳入 5 项 RCT，共计 198 例患者。汇总分析显示，肺康复组 ISWD（均数差 [MD] = 92.47 m，95%置信区间 [CI] 49.87，135.08；P < 0.0001）、6-MWD（MD = 31.01 m，95% CI 1.60，60.42；P = 0.04）和 FEV1（MD = 0.08 L，95% CI 0.04，0.12；P = 0.0002）的改善程度均优于对照组，但两组 SGRQ 和 LCQ 评分的改善程度无显著差异。
肺康复可改善支气管扩张症患者的运动能力和肺功能（尤其是 FEV1）。然而，由于现有研究数量和质量的限制，上述结论尚需进一步研究验证。
