Centre for Inflammation Research, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Respir Med. 2012 Dec;106(12):1647-54. doi: 10.1016/j.rmed.2012.08.004. Epub 2012 Sep 1.
The aim of our study was to assess the efficacy of pulmonary rehabilitation in addition to regular chest physiotherapy in non cystic fibrosis bronchiectasis.
Thirty patients with clinically significant bronchiectasis and limited exercise tolerance were randomized into either the control group receiving chest physiotherapy (8 weeks) or into the intervention group, receiving pulmonary rehabilitation in addition to chest physiotherapy (8 weeks). Both groups were encouraged to maintain their exercise program and or chest physiotherapy, following completion of the study.
End of training (8 weeks) No improvement in control group. In the intervention group, incremental shuttle walk test (ISWT) improved by 56.7 m (p = 0.03), endurance walk test (EWT) by 193.3 m (p = 0.01), Leicester Cough Questionnaire (LCQ) improved by 2.6 units (p < 0.001) and St. George's Respiratory Questionnaire (SGRQ) by 8 units (p < 0.001). At 20 weeks (12 weeks post end of training) No improvement in control group. In the intervention group, ISWT improved by 80 m (p = 0.04) and EWT by 247.5 m (p = 0.003). LCQ improved by 4.4 units (p < 0.001) and SGRQ by 4 units (p < 0.001).
Pulmonary rehabilitation in addition to regular chest physiotherapy, improves exercise tolerance and health related quality of life in non cystic fibrosis bronchiectasis and the benefit was sustained at 12 weeks post end of pulmonary rehabilitation. Clinical trials regn no. NCT00868075.
我们的研究目的是评估在非囊性纤维化支气管扩张症中，除常规胸部物理治疗外，肺康复的疗效。
30 名有临床显著支气管扩张和运动耐量有限的患者被随机分为对照组（接受胸部物理治疗[8 周]）或干预组（接受肺康复治疗[8 周]）。两组均在研究结束后被鼓励维持运动方案或胸部物理治疗。
训练结束（8 周）时，对照组无改善。在干预组中，增量穿梭步行试验（ISWT）增加了 56.7 米（p=0.03），耐力步行试验（EWT）增加了 193.3 米（p=0.01），莱斯特咳嗽问卷（LCQ）增加了 2.6 个单位（p<0.001），圣乔治呼吸问卷（SGRQ）增加了 8 个单位（p<0.001）。在 20 周（训练结束后 12 周）时，对照组无改善。在干预组中，ISWT 增加了 80 米（p=0.04），EWT 增加了 247.5 米（p=0.003）。LCQ 增加了 4.4 个单位（p<0.001），SGRQ 增加了 4 个单位（p<0.001）。
除常规胸部物理治疗外，肺康复还可提高非囊性纤维化支气管扩张症患者的运动耐量和健康相关生活质量，并且在肺康复结束后 12 周仍有获益。临床试验注册号：NCT00868075。
