活性氧中间体在内毒素肝毒性中的作用。

Role of reactive oxygen intermediates in the hepatotoxicity of endotoxin.

作者信息

Ghezzi P, Saccardo B, Bianchi M

出版信息

Immunopharmacology. 1986 Dec;12(3):241-4. doi: 10.1016/0162-3109(86)90008-1.

Abstract

Administration of endotoxin (2.5 micrograms/mouse, iv) to Corynebacterium parvum-pretreated (14 days earlier, 1 mg/mouse, i.v.) mice caused a rapid (90 min) decrease in liver cytochrome P450-dependent drug metabolism and an elevation of serum transaminase. The time course of the priming effect of C. parvum suggested that macrophages might be responsible for this sensitization to endotoxin. The antioxidant N-acetylcysteine (500 mg/kg) effectively protected against this depression of liver drug metabolism, thus supporting the hypothesis that liver macrophage-generated free radicals might mediate this hepatotoxic effect of endotoxin.

摘要

给经短小棒状杆菌预处理（14天前，静脉注射1毫克/只小鼠）的小鼠静脉注射内毒素（2.5微克/只小鼠），会导致肝脏细胞色素P450依赖性药物代谢迅速（90分钟）下降，血清转氨酶升高。短小棒状杆菌引发效应的时间进程表明，巨噬细胞可能是对内毒素产生这种致敏作用的原因。抗氧化剂N-乙酰半胱氨酸（500毫克/千克）有效预防了肝脏药物代谢的这种抑制，从而支持了肝脏巨噬细胞产生的自由基可能介导内毒素这种肝毒性作用的假说。