Matarazzo Laura, Hernandez Santana Yasmina E, Walsh Patrick T, Fallon Padraic G
Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, Dublin 8, Ireland; National Children's Research Centre, CHI Crumlin, Dublin 12, Ireland.
Cytokine. 2022 Jun;154:155890. doi: 10.1016/j.cyto.2022.155890. Epub 2022 Apr 21.
The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the functioning of innate and adaptive immunity and the genesis of inflammation. They are widely expressed in structural and immune cells with marked expression within barrier mucosal surfaces. In the lung, gut and skin, which are common entry sites for pathogens, they play essential functions in maintaining the functional integrity of the barrier and manage innate and adaptive immunity in response to insult and infections. In tissue sites, the IL-1 cytokines are tightly regulated by mechanisms involving decoy receptors and protease degradation. Dysregulation of these processes are associated with aberrant tissue inflammation leading to a number of inflammatory diseases. This review will address the roles of the different IL-1 cytokines at the lung, gut and skin barrier surfaces at homeostasis, and their roles as inflammatory mediators in diseases such as asthma, chronic obstructive pulmonary disease, inflammatory bowel diseases, atopic dermatitis and psoriasis.
细胞因子白细胞介素-1（IL-1）家族及其受体与先天性和适应性免疫功能以及炎症的发生有关。它们在结构细胞和免疫细胞中广泛表达，在屏障黏膜表面有明显表达。在肺、肠道和皮肤这些病原体常见的侵入部位，它们在维持屏障功能完整性以及应对损伤和感染时管理先天性和适应性免疫方面发挥着重要作用。在组织部位，IL-1细胞因子受到涉及诱饵受体和蛋白酶降解的机制的严格调控。这些过程的失调与异常的组织炎症相关，进而导致多种炎症性疾病。本综述将探讨不同的IL-1细胞因子在肺、肠道和皮肤屏障表面稳态时的作用，以及它们在哮喘、慢性阻塞性肺疾病、炎症性肠病、特应性皮炎和银屑病等疾病中作为炎症介质的作用。
