Biology and Biological Engineering, California Institute of Technology, 1200 E. California Blvd., MC 140-18, Pasadena, CA 91125, USA.
Biology and Biological Engineering, California Institute of Technology, 1200 E. California Blvd., MC 140-18, Pasadena, CA 91125, USA.
Curr Opin Immunol. 2022 Jun;76:102177. doi: 10.1016/j.coi.2022.102177. Epub 2022 Apr 21.
The intestinal microbiome influences neuroinflammatory disease in animal models, and recent studies have identified multiple pathways of communication between the gut and brain. Microbes are able to produce metabolites that enter circulation, can alter inflammatory tone in the intestines, periphery, and central nervous system (CNS), and affect trafficking of immune cells into the brain. Additionally, the vagus nerve that connects the enteric nervous system to the CNS is implicated in modulation of brain immune responses. As preclinical research findings and concepts are applied to humans, the potential impacts of the gut microbiome-brain axis on neuroinflammation represent exciting frontiers for further investigation.
肠道微生物组影响动物模型中的神经炎症性疾病，最近的研究已经确定了肠道和大脑之间的多种通讯途径。微生物能够产生进入循环的代谢产物，改变肠道、外周和中枢神经系统 (CNS) 的炎症基调，并影响免疫细胞向大脑的迁移。此外，连接肠神经系统和中枢神经系统的迷走神经也参与调节大脑免疫反应。随着临床前研究结果和概念在人类中的应用，肠道微生物组-大脑轴对神经炎症的潜在影响代表了进一步研究的令人兴奋的前沿领域。
