Malkova Anna M, Gubal Anna R, Petrova Anastasia L, Voronov Elena, Apte Ron N, Semenov Konstantin N, Sharoyko Vladimir V
Saint Petersburg State University, Saint Petersburg, Russia.
Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.
Immunology. 2023 Feb;168(2):203-216. doi: 10.1111/imm.13486. Epub 2022 May 7.
In recent years, pro-oncogenic mechanisms of the tumour microenvironment (ТМЕ) have been actively discussed. One of the main cytokines of the TМЕ is interleukin-1 beta (IL-1β), which exhibits proinflammatory properties. Some studies have shown an association between an increase in IL-1β levels and tumour progression. The purpose of this review is to analyse the pathogenic mechanisms induced by IL-1β in the TМЕ, as well as the diagnostic significance of the presence of IL-1β in patients with cancer and the efficacy of treatment with IL-1β inhibitors. According to the literature, IL-1β can induce an increase in tumour angiogenesis due to its effects on the differentiation of epithelial cells, pro-angiogenic molecule secretion and expression of adhesion molecules, thus increasing tumour growth and metastasis. IL-1β is also involved in the suppression of anti-tumour immune responses. The expression and secretion of IL-1β has been noted in various types of tumours. In some clinical studies, an elevated level of IL-1β was found to be associated with low efficacy of anti-cancer therapy and a poor prognosis. In most experimental and clinical studies, the use of IL-1β inhibitors contributed to a decrease in tumour mass and an increase in the response to anti-tumour drugs.
近年来，肿瘤微环境（TME）的促癌机制一直是人们积极讨论的话题。TME的主要细胞因子之一是白细胞介素-1β（IL-1β），它具有促炎特性。一些研究表明，IL-1β水平升高与肿瘤进展之间存在关联。本综述的目的是分析IL-1β在TME中诱导的致病机制，以及IL-1β在癌症患者中的诊断意义和IL-1β抑制剂的治疗效果。根据文献，IL-1β可通过影响上皮细胞分化、促血管生成分子分泌和黏附分子表达，诱导肿瘤血管生成增加，从而促进肿瘤生长和转移。IL-1β还参与抑制抗肿瘤免疫反应。在各种类型的肿瘤中都观察到了IL-1β的表达和分泌。在一些临床研究中，发现IL-1β水平升高与抗癌治疗效果不佳和预后不良有关。在大多数实验和临床研究中，使用IL-1β抑制剂有助于减少肿瘤体积，并增加对抗肿瘤药物的反应。
