Shi L, Wang Z R, Li T T, Linghu E Q, Wang F S
Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, 100039 Beijing, China.
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China,230001 Hefei, China.
Zhonghua Gan Zang Bing Za Zhi. 2022 Mar 20;30(3):237-243. doi: 10.3760/cma.j.cn501113-20220222-00083.
The high incidence of chronic liver disease is a serious threat to public health, and the current comprehensive internal medicine treatment is ineffective. Liver transplantation is limited by the shortage of liver source and post-transplant rejection, and thus unmet the clinical needs. More importantly, cell therapy shows great promise for the treatment of chronic liver disease. Over recent years, domestic and foreign scholars have carried out a variety of cell therapy preclinical and clinical trials for critical liver disease, and achieved certain results, providing new methods for the treatment of chronic liver diseases. This review discusses the cell therapy research status and application progress, various existing problems and challenges, and key issues of mesenchymal stem cells in the treatment of chronic liver diseases.
慢性肝病的高发病率对公众健康构成严重威胁，而目前的综合内科治疗效果不佳。肝移植受肝源短缺和移植后排斥反应的限制，无法满足临床需求。更重要的是，细胞治疗在慢性肝病治疗中显示出巨大潜力。近年来，国内外学者针对重症肝病开展了多种细胞治疗的临床前和临床试验，并取得了一定成果，为慢性肝病的治疗提供了新方法。本文综述了细胞治疗的研究现状与应用进展、现存的各种问题与挑战，以及间充质干细胞治疗慢性肝病的关键问题。
