Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Eur Arch Otorhinolaryngol. 2022 Sep;279(9):4541-4548. doi: 10.1007/s00405-022-07391-x. Epub 2022 Apr 24.
The aim of the present study was to investigate the predictive value of the fibrinogen/albumin ratio index (FARI), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) on the prognosis of patients with operable head and neck squamous cell carcinoma (HNSCC).
A cohort of 155 operable HNSCC patients were enrolled. Laboratory and clinical data were extracted from the patients' electronic medical record. The optimal cut-off values were determined by receiver operating characteristic (ROC) curves analysis. Clinicopathological characteristics of patients were compared via Chi-square test. Survival curves were analyzed by Kaplan-Meier method. The prognostic factors were evaluated by univariate and multivariate analyses via the Cox hazards regression analysis.
The median follow-up time was 31.7 months. An increased level of NLR was associated with later T stages, later N stages, and more advanced clinical stages(all P < 0.05). On univariate analyses, FARI, NLR, PLR, and N stage were correlated with progression-free survival (PFS) (all P < 0.05) as well as overall survival (OS) (all P < 0.05). And the clinical stage was only relevant to OS (P = 0.007). Multivariate Cox regression analysis revealed that FARI (HR 3.486, 95% CI 2.086-5.825, P < 0.001; HR 4.474, 95% CI 2.442-8.199, P < 0.001), NLR (HR 3.163, 95% CI 1.810-5.528, P < 0.001; HR 3.690, 95% CI 1.955-6.963, P < 0.001), and N stage (HR 1.718, 95% CI 1.058-2.789, P = 0.029; HR 1.777, 95% CI 1.024-3.084, P = 0.041) were independent prognostic factors for PFS and OS.
Our findings indicate that FARI and NLR are effective and convenient markers for predicting prognosis in operable HNSCC patients.
本研究旨在探讨纤维蛋白原/白蛋白比值指数（FARI）、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）对可手术头颈部鳞状细胞癌（HNSCC）患者预后的预测价值。
纳入了 155 例可手术 HNSCC 患者。从患者的电子病历中提取实验室和临床数据。通过受试者工作特征（ROC）曲线分析确定最佳截断值。通过卡方检验比较患者的临床病理特征。通过 Kaplan-Meier 法分析生存曲线。通过 Cox 风险回归分析进行单因素和多因素分析评估预后因素。
中位随访时间为 31.7 个月。NLR 水平升高与较晚的 T 分期、较晚的 N 分期和更晚期的临床分期相关（均 P<0.05）。单因素分析显示，FARI、NLR、PLR 和 N 分期与无进展生存期（PFS）（均 P<0.05）和总生存期（OS）（均 P<0.05）相关。临床分期仅与 OS 相关（P=0.007）。多因素 Cox 回归分析显示，FARI（HR 3.486，95%CI 2.086-5.825，P<0.001；HR 4.474，95%CI 2.442-8.199，P<0.001）、NLR（HR 3.163，95%CI 1.810-5.528，P<0.001；HR 3.690，95%CI 1.955-6.963，P<0.001）和 N 分期（HR 1.718，95%CI 1.058-2.789，P=0.029；HR 1.777，95%CI 1.024-3.084，P=0.041）是 PFS 和 OS 的独立预后因素。
我们的研究结果表明，FARI 和 NLR 是预测可手术 HNSCC 患者预后的有效且便捷的标志物。
